The Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Section 2142, Blegdamsvej 9, Copenhagen, Denmark.
Department of Cardiology, Copenhagen University Hospital, Gentofte, Denmark.
Europace. 2019 Jun 1;21(6):909-917. doi: 10.1093/europace/euz022.
Sudden cardiac death in the young (SCDY) accounts for a significant proportion of deaths among the young. The aim of this nationwide study was to examine temporal changes in incidence and causes of SCDY in Denmark in 2000-2009. During this 10-year period, several public and private health initiatives were undertaken to decrease morbidity and mortality in Denmark.
All deaths among persons aged 1-35 years in Denmark in 2000-2009 (23.7 million person-years) were included. Death certificates, autopsy reports, discharge summaries, and data from nationwide administrative registries were used to identify SCDY cases. Sudden cardiac death in the young incidence rates were age-adjusted and sex-adjusted using direct standardization. Temporal changes in standardized SCDY incidence rates were reported as average annual percent changes. In the 10-year study period, there were 8756 deaths, of which we identified 635 (7%) SCDY cases. For these SCDY cases, median age at death was 29 years and 68% were men. Standardized incidence of SCDY decreased from 3.1 per 100 000 person-years in 2000 [95% confidence interval (CI) 2.4-3.8] to 2.5 per 100 000 person-years in 2009 (95% CI 1.9-3.2). This corresponds to an average annual percent change of -3.0% (95% CI -5.8 to -0.1). The distribution of major causes of SCDY did not change significantly throughout the study period.
Incidence of SCDY decreased significantly from 2000 through 2009 in Denmark with an average annual percent change of -3%. Further research is needed to elucidate underlying causes of this development.
年轻人中的心脏性猝死（SCDY）占年轻人死亡的很大比例。本项全国性研究旨在检查 2000-2009 年丹麦 SCDY 的发病率和病因的时间变化。在此 10 年期间，丹麦采取了多项公共和私人卫生举措来降低发病率和死亡率。
纳入 2000-2009 年丹麦年龄在 1-35 岁之间的所有死亡者（2370 万人年）。使用死亡证明、尸检报告、出院记录和全国性行政登记数据来识别 SCDY 病例。使用直接标准化法对年轻人心脏性猝死的发病率进行年龄和性别调整。报告标准化 SCDY 发病率的时间变化为平均年百分比变化。在 10 年的研究期间，有 8756 人死亡，其中我们确定了 635 例（7%）SCDY 病例。这些 SCDY 病例的死亡时中位年龄为 29 岁，68%为男性。SCDY 的标准化发病率从 2000 年的每 100000 人年 3.1 例（95%可信区间 2.4-3.8）降至 2009 年的每 100000 人年 2.5 例（95%可信区间 1.9-3.2）。这相当于平均每年下降 3.0%（95%可信区间-5.8 至-0.1）。SCDY 的主要病因分布在整个研究期间没有明显变化。
丹麦的 SCDY 发病率从 2000 年至 2009 年显著下降，平均每年下降 3%。需要进一步研究阐明这一发展的潜在原因。
