Winkel Bo Gregers, Risgaard Bjarke, Bjune Thea, Jabbari Reza, Lynge Thomas Hadberg, Glinge Charlotte, Bundgaard Henning, Haunsø Stig, Tfelt-Hansen Jacob
Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, 2142, Blegdamsvej 9, 2100, Copenhagen O, Denmark.
BMC Cardiovasc Disord. 2017 Jan 7;17(1):19. doi: 10.1186/s12872-016-0446-5.
Hitherto, sudden cardiac death (SCD) in the young has been described with no distinction between genders. SCD occurs more often in men (SCDm) than women (SCDw), but this disparity is not understood and has not been investigated systematically in a nationwide setting. Our objective was to report gender differences in SCD in the young in a nationwide (Denmark) setting.
All deaths in persons aged 1-35 years nationwide in Denmark between 2000 and 2009 were included. Death certificates and autopsy reports were obtained. The extensive health care registries in Denmark were used to investigate any known disease prior to death. SCDw were compared to SCDm.
During the 10-year study period there were a total of 8756 deaths in 23.7 million person-years. In total, 635 deaths were SCD. SCDw constituted 205 deaths (32%). Women had a higher proportion of witnessed deaths (51 vs. 41%, p = 0.02) and died less often in a public place (16 vs. 26%, p = 0.01). Age at death, ratios of autopsies and sudden unexplained deaths, and comorbidities, did not differ. Causes of SCD were largely comparable between genders. The incidence rate of SCDw was half of that of SCDm (1.8 vs. 3.6 per 100,000 person-years, incidence rate ratio 2.0 (95% CI 1.7-2.4), p < 0.01).
Incidence rate ratio of SCDm vs SCDw is 2. Young SCDw and SCDm are equally investigated, have comparable comorbidity, and causes of SCD. SCD due to potentially inherited cardiac diseases is less often in young women and could reflect a protection of female gender.
迄今为止，年轻人群中心脏性猝死（SCD）的描述未区分性别。SCD在男性（SCDm）中比女性（SCDw）更常见，但这种差异尚不清楚，且未在全国范围内进行系统研究。我们的目的是报告丹麦全国范围内年轻人群SCD的性别差异。
纳入2000年至2009年丹麦全国范围内1至35岁人群的所有死亡病例。获取死亡证明和尸检报告。利用丹麦广泛的医疗保健登记系统调查死亡前的任何已知疾病。将SCDw与SCDm进行比较。
在为期10年的研究期间，2370万人年中共有8756例死亡。总共有635例死亡为SCD。SCDw占205例死亡（32%）。女性目击死亡的比例更高（51%对41%，p = 0.02），在公共场所死亡的频率更低（16%对26%，p = 0.01）。死亡年龄、尸检和不明原因猝死的比例以及合并症并无差异。SCD的病因在性别之间基本相当。SCDw的发病率是SCDm的一半（每10万人年1.8例对3.6例，发病率比为2.0（95%CI 1.7 - 2.4），p < 0.01）。
SCDm与SCDw的发病率比为2。年轻的SCDw和SCDm接受相同程度的调查，合并症相当，SCD病因也相同。年轻女性中由潜在遗传性心脏病导致的SCD较少，这可能反映了女性性别受到的一种保护。
