Sax H C, Talamini M A, Fischer J E
Arch Surg. 1986 Mar;121(3):358-66. doi: 10.1001/archsurg.1986.01400030120019.
The branched-chain amino acids (BCAAs)--leucine, isoleucine, and valine--share unique biochemical properties that may make them useful in altered physiologic states. They can be metabolized independently of liver function to provide energy, other amino acids, or small nitrogenous compounds. This unique ability makes the BCAAs a desirable supplement in liver disease with encephalopathy and, to a lesser extent, in sepsis with hepatic dysfunction. Furthermore, the BCAAs play a role in the regulation of protein synthesis, suggesting beneficial effects in catabolic states such as postoperative stress, trauma, renal failure, and burns. However, initial studies in these areas have presented equivocal results.
支链氨基酸（BCAAs）——亮氨酸、异亮氨酸和缬氨酸——具有独特的生化特性，这可能使它们在生理状态改变时发挥作用。它们可以独立于肝功能进行代谢，以提供能量、其他氨基酸或含氮小分子化合物。这种独特的能力使BCAAs成为肝病合并肝性脑病时理想的补充剂，在程度较轻的肝功能不全的脓毒症中也适用。此外，BCAAs在蛋白质合成调节中发挥作用，表明在分解代谢状态如术后应激、创伤、肾衰竭和烧伤中具有有益作用。然而，这些领域的初步研究结果并不明确。
