他汀类药物使用与头颈部癌症呈负相关：汉族人群基于人群的病例对照研究。
Inverse association between statin use and head and neck cancer: Population-based case-control study in Han population.
机构信息
Graduate Institute of Life Science, National Defense Medical Center, Taipei, Taiwan.
Sleep Research Center, Taipei Medical University Hospital, Taipei, Taiwan.
出版信息
Head Neck. 2019 May;41(5):1193-1198. doi: 10.1002/hed.25501. Epub 2019 Feb 26.
BACKGROUND
This case-control study aimed to find the relationship between prior statin use and head and neck cancer occurrence using a large population-based database.
METHODS
This study used claims data from the Taiwan Longitudinal Health Insurance Database. We included 5515 patients with head and neck cancer as cases and 5515 propensity score-matched patients without head and neck cancer as controls. Conditional logistic regressions were performed to investigate the relationship between head and neck cancer and prior statin exposure.
RESULTS
Of the 11 030 total sampled patients, 16.95% had previously received prescriptions for statins. In addition, statin exposure was found in 15.99% of cases and 17.91% of controls. The logistic regression also revealed that the adjusted odds ratio of prior statin exposure for cases was 0.86 (95% confidence interval: 0.77-0.95) compared to propensity score-matched controls.
CONCLUSION
This study found an inverse association between statin usage and head and neck cancer occurrence.
背景
本病例对照研究旨在利用大型基于人群的数据库，探讨他汀类药物使用与头颈部癌症发生之间的关系。
方法
本研究使用了来自台湾纵向健康保险数据库的理赔数据。我们纳入了 5515 例头颈部癌症患者作为病例，5515 例匹配了倾向得分且无头颈部癌症的患者作为对照。采用条件逻辑回归分析头颈部癌症与他汀类药物暴露的关系。
结果
在总共 11030 例抽样患者中，有 16.95%的患者之前曾开具过他汀类药物处方。此外，15.99%的病例和 17.91%的对照患者有他汀类药物暴露。逻辑回归还显示，与匹配的倾向得分对照相比，病例中先前使用他汀类药物的调整后比值比为 0.86（95%置信区间：0.77-0.95）。
结论
本研究发现他汀类药物使用与头颈部癌症发生之间存在负相关关系。
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