炎症生物标志物与头颈部鳞状细胞癌患者使用他汀类药物之间的关联。
The association between inflammatory biomarkers and statin use among patients with head and neck squamous cell carcinoma.
机构信息
Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
出版信息
Head Neck. 2022 Jun;44(6):1393-1403. doi: 10.1002/hed.27040. Epub 2022 Mar 25.
BACKGROUND
Tumor-infiltrating lymphocytes (TILs) and cytokines are associated with prognosis among patients with head and neck squamous cell carcinoma (HNSCC). Statins (cholesterol-lowering drugs) may improve HNSCC prognosis, particularly in human papillomavirus (HPV)-positive cases, but the mechanism remains unclear.
METHODS
Statin use was collected from medical records for HNSCC cases (2008-2014). TILs were counted in tumor tissue, and a total weighted score (TILws) was created. Cytokines were measured in blood. The associations between statins and biomarkers were estimated using logistic (biomarker categories: <median, ≥median) and linear regression models (log-transformed continuous biomarkers) adjusted for age, smoking, and comorbidities.
RESULTS
We observed a positive association between statins and TILs among HPV-positive patients (TILws odds ratio [OR] = 2.80; 95% CI = 1.03-7.61), but no association among HPV-negative patients. We observed no association between statins and cytokines.
CONCLUSIONS
Statins may influence TILs in HPV-positive patients. This may be the mechanism through which they improve prognosis in HPV-positive HNSCC patients.
背景
肿瘤浸润淋巴细胞（TILs）和细胞因子与头颈部鳞状细胞癌（HNSCC）患者的预后相关。他汀类药物（降低胆固醇的药物）可能改善 HNSCC 的预后，尤其是在人乳头瘤病毒（HPV）阳性的情况下，但机制尚不清楚。
方法
从 HNSCC 病例的病历中收集了他汀类药物的使用情况（2008-2014 年）。在肿瘤组织中计算了 TILs，并创建了总加权评分（TILws）。在血液中测量了细胞因子。使用逻辑回归（生物标志物类别：<中位数，≥中位数）和线性回归模型（对数转换的连续生物标志物）调整年龄、吸烟和合并症，估计了他汀类药物与生物标志物之间的关联。
结果
我们观察到在 HPV 阳性患者中，他汀类药物与 TILs 之间存在正相关（TILws 比值比 [OR] = 2.80；95%置信区间 [CI] = 1.03-7.61），但在 HPV 阴性患者中没有这种相关性。我们没有观察到他汀类药物与细胞因子之间的关联。
结论
他汀类药物可能影响 HPV 阳性患者的 TILs。这可能是它们改善 HPV 阳性 HNSCC 患者预后的机制。
Zotero 插件