Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470, Mülheim an der Ruhr, Germany.
Laboratorium für Organische Chemie, ETH Zürich, Vladimir-Prelog-Weg 3, HCI, 8093, Zürich, Switzerland.
Angew Chem Int Ed Engl. 2019 May 6;58(19):6444-6448. doi: 10.1002/anie.201812396. Epub 2019 Feb 27.
A completely atom economical palladium-catalyzed addition reaction has been developed to stereoselectively access functionalized tetrasubstituted alkenyl iodides. The palladium catalyst, which bears an electron-poor bidentate ligand rarely employed in catalysis, is essential to promote the high yielding and chemoselective intermolecular reaction between equimolar amounts of an alkyne and an aryl iodide. This new carbohalogenation reaction is an attractive alternative to traditional synthetic methods, which rely on multistep synthetic sequences and protecting-group manipulations.
发展了一种完全原子经济性的钯催化加成反应，以立体选择性地获得功能化的四取代烯基碘化物。该钯催化剂负载了一种在催化中很少使用的缺电子双齿配体，对于促进等摩尔量的炔烃和芳基碘化物之间的高产率和化学选择性的分子间反应是必不可少的。这种新的碳卤化反应是对传统合成方法的一种有吸引力的替代方法，传统合成方法依赖于多步合成序列和保护基操作。
