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过渡金属催化下酰氯的不同反应活性

The Divergent Reactivity of Acid Chlorides Under Transition Metal Catalysis.

作者信息

Denton Elliott H, Stepanović Olivera, Morandi Bill

机构信息

Laboratorium für Organische Chemie (D-CHAB), ETH Zürich, Vladimir-Prelog-Weg 3, HCI, 8093, Zürich, Switzerland.

出版信息

Chemistry. 2024 Dec 2;30(67):e202401852. doi: 10.1002/chem.202401852. Epub 2024 Nov 6.

DOI:10.1002/chem.202401852
PMID:39506462
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11610683/
Abstract

The power and ability of catalysis to build multiple C-C bonds in a single step has had a transformative impact on organic synthesis. While the reactivity of organohalides with metal catalysts is widely appreciated, the related and more intricate reactivity of acid chlorides is less so, despite their use as common reagents in synthesis. Here, we review the transformations of acid chlorides in combination with unsaturated C-C bonds catalyzed by palladium, rhodium, or iridium and provide an outlook for future research opportunities.

摘要

催化在一步反应中构建多个碳-碳键的能力对有机合成产生了变革性影响。虽然有机卤化物与金属催化剂的反应活性已广为人知，但酰氯的相关且更为复杂的反应活性却鲜为人知，尽管它们在合成中作为常用试剂使用。在此，我们综述了钯、铑或铱催化下酰氯与不饱和碳-碳键的反应，并对未来的研究机会进行了展望。

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