重大精神障碍情绪感知的神经系统自发性低频波动：各频段的幅度相似性和差异性。
Spontaneous low-frequency fluctuations in the neural system for emotional perception in major psychiatric disorders: amplitude similarities and differences across frequency bands.
机构信息
From the Department of Radiology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, PR China (Chang, Jiang, Wang, Wei, Xu); the Department of Psychiatry, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, PR China (Tang, Q. Zhou, Y. Zhou); the Brain Function Research Section, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, PR China (Chang, Edmiston, Jiang, Tang, Wang, Wei, Xu, Q. Zhou, Y. Zhou); the Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (Womer); the Division of Biostatistics, University of California, Berkeley, Berkeley, CA (Huang, Ye); the CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, PR China (Zuo); and the Department of Psychology, University of Chinese Academy of Sciences, Beijing, PR China (Zuo).
出版信息
J Psychiatry Neurosci. 2019 Mar 1;44(2):132-141. doi: 10.1503/jpn.170226.
BACKGROUND
Growing evidence indicates both shared and distinct features of emotional perception in schizophrenia, bipolar disorder and major depressive disorder. In these disorders, alterations in spontaneous low-frequency fluctuations have been reported in the neural system for emotional perception, but the similarities and differences in the amplitude of low-frequency fluctuation (ALFF) across the 3 disorders are unknown.
METHODS
We compared ALFF and its signal balance in the neural system for emotional perception at 2 frequency bands (slow-5 and slow-4) in 119 participants with schizophrenia, 100 with bipolar disorder, 123 with major depressive disorder and 183 healthy controls. We performed exploratory Pearson partial correlation analyses to determine the relationship between ALFF signal balance and clinical variables.
RESULTS
We observed commonalities in ALFF change patterns across the 3 disorders for emotional perception neural substrates, such as increased ALFF in the anterior cerebrum (including subcortical, limbic, paralimbic and heteromodal cortical regions) and decreased ALFF in the posterior visual cortices. Schizophrenia, bipolar disorder and major depressive disorder showed significantly decreased ALFF signal balance in the neural system for emotional perception at both slow-5 and slow-4 frequency bands, with the greatest alterations for schizophrenia, followed by bipolar disorder and major depressive disorder. We found a negative correlation between ALFF signal balance and negative/disorganized symptoms in slow-4 across the 3 disorders.
LIMITATIONS
The relatively broad age range in our sample and the cross-sectional study design may not account for our findings.
CONCLUSION
The extent of the commonalities we observed further support the concept of core neurobiological disruptions shared among the 3 disorders; ALFF signal balance could be an important neuroimaging marker for the diagnosis and treatment of schizophrenia, bipolar disorder and major depressive disorder.
背景
越来越多的证据表明，精神分裂症、双相情感障碍和重度抑郁症在情绪感知方面存在共同和独特的特征。在这些疾病中，已经报道了情绪感知神经系统中自发低频波动的改变，但在这 3 种疾病中，低频波动幅度（ALFF）的相似性和差异性尚不清楚。
方法
我们比较了 119 名精神分裂症患者、100 名双相情感障碍患者、123 名重度抑郁症患者和 183 名健康对照组在 2 个频带（慢-5 和慢-4）的情绪感知神经系统中的 ALFF 和其信号平衡。我们进行了探索性的 Pearson 偏相关分析，以确定 ALFF 信号平衡与临床变量之间的关系。
结果
我们观察到情绪感知神经基础上，3 种疾病的 ALFF 变化模式存在共性，如前脑（包括皮质下、边缘、边缘旁和异模态皮质区域）的 ALFF 增加和后视觉皮质的 ALFF 减少。精神分裂症、双相情感障碍和重度抑郁症在慢-5 和慢-4 频带的情绪感知神经系统中均表现出明显的 ALFF 信号平衡降低，其中精神分裂症的改变最大，其次是双相情感障碍和重度抑郁症。我们发现 3 种疾病的慢-4 中，ALFF 信号平衡与阴性/紊乱症状呈负相关。
局限性
我们样本的年龄范围相对较宽，以及横断面研究设计可能无法解释我们的发现。
结论
我们观察到的共同程度进一步支持了这 3 种疾病存在核心神经生物学紊乱的概念；ALFF 信号平衡可能是精神分裂症、双相情感障碍和重度抑郁症诊断和治疗的一个重要神经影像学标志物。
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