The First Hospital of Qiqihaer City, Qiqihaer, Heilongjiang, 161005, PR China.
School of Medical, Shihezi University, Shihezi, Xinjiang, PR China.
Biomark Med. 2019 Feb;13(3):219-234. doi: 10.2217/bmm-2018-0086. Epub 2019 Feb 27.
The role of octamer-binding transcription factor 4 (Oct4) in gastric cancer (GC) progression is still under debate and reported results are inconsistent. Therefore, we conducted a meta-analysis to evaluate the clinicopathological and prognostic significance of Oct4 expression in patients with GC.
MATERIALS & METHODS: Relevant articles were retrieved from a diverse number of databases, and meta-analysis was completed using STATA software 12.0.
Total of 21 studies were included in this analysis (3209 samples). Expression of Oct4 was associated with incidence, tumor size, lymph node metastasis, histological differentiation, pTNM stage, tumor depth of infiltration, vascular invasion and distal metastasis. Additionally, Oct4 expression was correlated with poor overall survival rate.
The Oct4 overexpression suggested aggressive biological behaviors and imply that Oct4 may be a useful prognostic biomarker in gastric cancers.
八聚体结合转录因子 4（Oct4）在胃癌（GC）进展中的作用仍存在争议，且报道结果不一致。因此，我们进行了一项荟萃分析，以评估 Oct4 表达在 GC 患者中的临床病理和预后意义。
从多个数据库中检索相关文献，并使用 STATA 软件 12.0 完成荟萃分析。
本分析共纳入 21 项研究（3209 例样本）。Oct4 的表达与发病率、肿瘤大小、淋巴结转移、组织学分化、pTNM 分期、肿瘤浸润深度、血管侵犯和远处转移有关。此外，Oct4 表达与总生存率降低相关。
Oct4 过表达提示侵袭性的生物学行为，表明 Oct4 可能是胃癌中一种有用的预后生物标志物。
