氯贝酸对大鼠肾脏和肠黏膜中1-酰基甘油磷酸胆碱酰基转移酶的诱导作用。
Inducing effects of clofibric acid on 1-acylglycerophosphorylcholine acyltransferase in kidney and intestinal mucosa of rats.
作者信息
Kawashima Y, Hirose A, Hirose Y, Adachi T, Kozuka H
出版信息
Biochim Biophys Acta. 1986 Feb 28;875(3):549-53.
Administration of p-chlorophenoxyisobutyric acid (clofibric acid) markedly increased the activity of microsomal 1-acylglycerophosphorylcholine (1-acyl-GPC) acyltransferase in kidney, intestinal mucosa and liver, but not in brain, heart, lung, spleen, testis or skeletal muscle. In both kidney and liver, a marked dose-dependent increase in the activities of both microsomal 1-acyl-GPC acyltransferase and peroxisomal beta-oxidation was observed. In the rats treated with clofibric acid at a relatively low dose, the increase in the activity of 1-acyl-GPC acyltransferase in kidney was more marked than that in liver. The extent of the relative increase in the activity of 1-acyl-GPC acyltransferase to the activity of peroxisomal beta-oxidation in kidney was more marked than that in liver. The increased activity of 1-acyl-GPC acyltransferase in both kidney and liver lasted throughout the 8-week treatment period of rat with clofibric acid.
对氯苯氧异丁酸（氯贝酸）的给药显著增加了肾脏、肠黏膜和肝脏中微粒体1-酰基甘油磷酸胆碱（1-酰基-GPC）酰基转移酶的活性，但在脑、心脏、肺、脾脏、睾丸或骨骼肌中未增加。在肾脏和肝脏中，均观察到微粒体1-酰基-GPC酰基转移酶和过氧化物酶体β-氧化活性的显著剂量依赖性增加。在用相对低剂量氯贝酸处理的大鼠中，肾脏中1-酰基-GPC酰基转移酶活性的增加比肝脏中更明显。肾脏中1-酰基-GPC酰基转移酶活性相对于过氧化物酶体β-氧化活性的相对增加程度比肝脏中更明显。在用氯贝酸对大鼠进行的8周治疗期间，肾脏和肝脏中1-酰基-GPC酰基转移酶活性的增加持续存在。
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