Farrell S, Vogel J, Bieber L L
Biochim Biophys Acta. 1986 Mar 21;876(1):175-7. doi: 10.1016/0005-2760(86)90332-2.
[1-14C]Acetyl-L-carnitine was injected into fed and fasted mice and the time-course of distribution of 14C in various tissues and tissue components was determined. The major product was 14CO2. However, considerable quantities of radioactivity were localized in liver with much smaller quantities in heart, brain, skeletal muscle and kidney. Most of the 14C in liver was located in the fatty acids of phospholipids and triacylglycerols within 10 min after injection. The data demonstrate that the acetyl moiety of acetylcarnitine rapidly enters lipid biosynthetic pools in liver.
将[1-14C]乙酰-L-肉碱注射到喂食和禁食的小鼠体内，测定了14C在各种组织和组织成分中的分布时间进程。主要产物是14CO2。然而，相当数量的放射性定位于肝脏，心脏、大脑、骨骼肌和肾脏中的数量则少得多。注射后10分钟内，肝脏中大部分的14C位于磷脂和三酰甘油的脂肪酸中。数据表明，乙酰肉碱的乙酰部分迅速进入肝脏中的脂质生物合成池。
