丙酰肉碱对大鼠心脏线粒体的回补作用
Anaplerotic effect of propionyl carnitine in rat heart mitochondria.
作者信息
Tassani V, Cattapan F, Magnanimi L, Peschechera A
机构信息
Dept. of Biological Chemistry, University of Padova, Italy.
出版信息
Biochem Biophys Res Commun. 1994 Mar 15;199(2):949-53. doi: 10.1006/bbrc.1994.1321.
Carnitine and propionyl carnitine both increase production of 14CO2 from [1-14C]pyruvate but only the latter, in a process inhibited by malonate, increases oxygen uptake and 14CO2 evolution from [2-14C]pyruvate. Carnitine increases the rate of formation of acetyl carnitine from pyruvate to a greater extent than propionyl carnitine. These effects of carnitine and propionyl carnitine are not detectable in mitochondria (e.g., rat liver) deficient in carnitine acetyl transferase activity.
肉碱和丙酰肉碱都能增加[1-¹⁴C]丙酮酸生成¹⁴CO₂的量，但只有后者（该过程受丙二酸抑制）能增加氧气摄取以及[2-¹⁴C]丙酮酸的¹⁴CO₂释放量。肉碱比丙酰肉碱能更大程度地提高丙酮酸生成乙酰肉碱的速率。在缺乏肉碱乙酰转移酶活性的线粒体（如大鼠肝脏）中，未检测到肉碱和丙酰肉碱的这些作用。
Zotero 插件