Slogoff S, Keats A S, Ott E
JAMA. 1978 Sep 29;240(14):1487-90.
The relationship between long-term propranolol hydrochloride therapy and subsequent coronary bypass operation was prospectively investigated in 119 patients who were grouped three ways: propranolol therapy continued in full dosage to operation (group A), propranolol therapy discontinued or tapered 24 to 72 hours preoperatively (group B), and no preoperative propranolol therapy (control group). During preoperative hospitalization, one patient in each group A and the control group suffered an increase in anginal symptoms compared with 15 patients in group B, three of whom also had new ventricular arrhythmias. During anesthesia up to the period of cardiopulmonary bypass, 26% of group A patients showed signs of ischemia (eg, ST segment deviation or ventricular arrhythmias) as compared with 51% of the control group and 70% of group B. Hypotension and bradycardia were not more common in group A patients. No differences among groups were noted in case of emergence from bypass, need for cardiac stimulants, or mortality.
前瞻性研究了119例患者长期服用盐酸普萘洛尔治疗与随后冠状动脉搭桥手术之间的关系，这些患者被分为三组：手术前一直以全剂量持续服用普萘洛尔治疗（A组）；术前24至72小时停用或逐渐减少普萘洛尔治疗（B组）；术前未进行普萘洛尔治疗（对照组）。在术前住院期间，A组和对照组各有1例患者与B组的15例患者相比出现心绞痛症状加重，其中B组3例患者还出现了新的室性心律失常。在麻醉直至体外循环期间，A组26%的患者出现缺血迹象（如ST段偏移或室性心律失常），而对照组为51%，B组为70%。A组患者低血压和心动过缓并不更常见。在脱离体外循环、需要心脏兴奋剂或死亡率方面，各组之间未观察到差异。
