药物戒断综合征——文献综述
Drug withdrawal syndromes-- a literature review.
作者信息
Hodding G C, Jann M, Ackerman I P
出版信息
West J Med. 1980 Nov;133(5):383-91.
Abstract
Drug withdrawal syndromes reportedly have been caused by numerous pharmacological agents, but only a few drugs have been adequately studied in this regard. Criteria for evaluating drug withdrawal syndromes have been proposed. Sedative-hypnotic agents, opiates, corticosteroids, clonidine, tricyclic antidepressant medications and beta-adrenergic blocking agents meet the criteria for such syndromes. Gradual tapering of the dose of these drugs is recommended when therapy must be discontinued. Whether or not other drugs cause rebound reactions is questionable, but caution should be used when discontinuing drugs for which numerous reports of withdrawal syndromes exist.
摘要
据报道，多种药物可引发撤药综合征，但只有少数几种药物在这方面得到了充分研究。已提出评估撤药综合征的标准。镇静催眠药、阿片类药物、皮质类固醇、可乐定、三环类抗抑郁药和β-肾上腺素能阻滞剂符合此类综合征的标准。当必须停药时，建议逐渐减少这些药物的剂量。其他药物是否会引起反跳反应尚存在疑问，但对于有大量撤药综合征报告的药物，停药时应谨慎。
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