豚鼠 copeptin。血管加压素前体的糖肽结构域。

Guinea pig copeptin. The glycopeptide domain of the vasopressin precursor.

作者信息

Chauvet M T, Chauvet J, Acher R

出版信息

FEBS Lett. 1986 Mar 3;197(1-2):169-72. doi: 10.1016/0014-5793(86)80320-9.

Abstract

The vasopressin precursor is composed of 3 domains in line, namely vasopressin, MSEL-neurophysin and a glycopeptide referred to as copeptin, which are separated during the processing. In guinea pig neurohypophysis, the precursor is partially processed so that a two-domain fragment, MSEL-neurophysin--copeptin, can be found along with free MSEL-neurophysin adn copeptin. Guinea pig copeptin has been sequenced. It is a glycopeptide composed of 38 amino acid residues rather than the 39 found in other mammalian copeptins. Compared with other copeptins, that from guinea pig shows a few substitutions and the deletion of one acidic residue, probably in position 32. This deletion might be responsible for incomplete cleavage by the trypsin-like processing enzyme.

摘要

血管加压素前体由三个呈线性排列的结构域组成，即血管加压素、MSEL-神经垂体素和一种称为 copeptin 的糖肽，它们在加工过程中被分开。在豚鼠神经垂体中，前体被部分加工，因此可以发现一个两结构域片段，即 MSEL-神经垂体素——copeptin，同时还有游离的 MSEL-神经垂体素和 copeptin。豚鼠 copeptin 已被测序。它是一种由 38 个氨基酸残基组成的糖肽，而非其他哺乳动物 copeptin 中的 39 个。与其他 copeptin 相比，豚鼠的 copeptin 有一些替换，并且缺失了一个酸性残基，可能在第 32 位。这种缺失可能是由类胰蛋白酶加工酶不完全切割所致。