[豚鼠和大鼠中三结构域血管加压素前体成熟的差异：豚鼠中一种神经垂体素 - copeptin片段的鉴定]
[Difference in the maturation of the three-domain vasopressin precursor in the guinea-pig and rat: identification of a neurophysin-copeptin fragment in the guinea pig].
作者信息
Chauvet M T, Chauvet J, Acher R
出版信息
C R Acad Sci III. 1987;304(1):37-40.
Vasopressin, MSEL-neurophysin and copeptin have been isolated from guinea pig and rat neurophypophyses and their amino acid sequences have been determined. Whereas in rat processing of the three-domain precursor is complete, in the guinea pig a 132-residue fragment including MSEL-neurophysin and copeptin linked by an arginine residue has been characterized. This incomplete maturation (20% of the precursor) could be due to a deletion of an acidic residue in guinea pig copeptin when compared with other mammalian copeptins.
血管加压素、MSEL-神经垂体素和 copeptin 已从豚鼠和大鼠的神经垂体中分离出来，并且它们的氨基酸序列已被确定。在大鼠中，三结构域前体的加工是完整的，而在豚鼠中，已鉴定出一个由精氨酸残基连接的包含 MSEL-神经垂体素和 copeptin 的 132 个残基的片段。与其他哺乳动物的 copeptin 相比，豚鼠 copeptin 中酸性残基的缺失可能导致这种不完全成熟（前体的 20%）。
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