Toyoda J, Hisayama T, Takayanagi I
Gen Pharmacol. 1986;17(1):89-91. doi: 10.1016/0306-3623(86)90016-9.
In organ bath studies, the selectivity of isolated femoral vein and artery of rabbit to isosorbide dinitrate (ISDN), 5-isosorbide mononitrate (ISMN), major metabolite of ISDN, and glyceryl trinitrate (GTN) was compared. The femoral vein and artery contracted by norepinephrine were relaxed by all the nitro compounds dose-dependently. Potency order was GTN greater than ISDN greater than ISMN. The maximum inhibitory responses to the nitrocompounds and their pIC50 values (negative logarithms of doses to induce the 50% response) were greater in the femoral vein than in the femoral artery. For ISMN a 3 times greater sensitivity of femoral vein than of femoral artery was found.
在器官浴槽研究中，比较了兔离体股静脉和股动脉对硝酸异山梨酯（ISDN）、5-单硝酸异山梨酯（ISMN，ISDN的主要代谢产物）和硝酸甘油（GTN）的选择性。去甲肾上腺素收缩的股静脉和股动脉被所有硝基化合物剂量依赖性地舒张。效价顺序为GTN＞ISDN＞ISMN。硝基化合物的最大抑制反应及其pIC50值（诱导50%反应的剂量的负对数）在股静脉中比在股动脉中更大。对于ISMN，发现股静脉的敏感性比股动脉高3倍。
