Toyoda J, Hisayama T, Takayanagi I
Gen Pharmacol. 1987;18(1):95-7. doi: 10.1016/0306-3623(87)90177-7.
In organ bath studies, effects of isosorbide dinitrate (ISDN), 5-isosorbide mononitrate (ISMN), a major metabolite of ISDN, and glyceryl trinitrate (GTN) on Ca-uptake into Ca-stores and Ca-release from Ca-stores were tested in the rabbit isolated femoral veins and femoral arteries. ISDN (10(-4) M) and GTN (10(-4) M) inhibited Ca-uptake in the femoral veins but not in the femoral arteries. The selectivity to the femoral veins was not observed in ISMN (10(-3) M) and GTN (3 X 10(-6) M). All the nitro compounds inhibited Ca-release from Ca-stores more effectively in the femoral veins than in the femoral arteries. The present results may explain the selectivity of the nitro compounds to the femoral veins.
在器官浴实验中，在兔离体股静脉和股动脉中测试了硝酸异山梨酯（ISDN）、5-单硝酸异山梨酯（ISMN，ISDN的主要代谢产物）和硝酸甘油（GTN）对钙储存库钙摄取及从钙储存库钙释放的影响。ISDN（10⁻⁴ M）和GTN（10⁻⁴ M）抑制股静脉中的钙摄取，但不抑制股动脉中的钙摄取。在ISMN（10⁻³ M）和GTN（3×10⁻⁶ M）中未观察到对股静脉的选择性。所有硝基化合物抑制股静脉中钙储存库的钙释放比抑制股动脉中的更有效。目前的结果可能解释了硝基化合物对股静脉的选择性。
