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转化生长因子-β亚型在卵巢癌中的预后价值。

Prognostic Values of Transforming Growth Factor-Beta Subtypes in Ovarian Cancer.

机构信息

Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.

出版信息

Biomed Res Int. 2020 Apr 12;2020:2170606. doi: 10.1155/2020/2170606. eCollection 2020.

DOI:10.1155/2020/2170606
PMID:32351985
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7174935/
Abstract

PURPOSE

To explore the potential role of the transforming growth factor-beta (TGF-) subtypes in the prognosis of ovarian cancer patients. . The prognostic roles of individual TGF- subtypes in women with ovarian cancer were retrieved from the Kaplan-Meier plotter (KM plotter) database. In addition, the Oncomine database and immunohistochemistry were used to observe the mRNA and protein expression of TGF- subtypes between human ovarian carcinoma and normal ovarian samples, respectively.

RESULTS

TGF-1 and TGF-4 were totally uncorrelated with survival outcomes in women with ovarian cancer. Increased TGF-2 and TGF-3 mRNA expression was markedly related to unfavorable prognosis, especially in women with serous, poorly differentiated, and late-stage ovarian carcinoma. High expression levels of TGF-2 were related to worse progression-free survival (PFS) while TGF-3 was linked to unfavorable overall survival (OS) and PFS in women with TP53-mutated ovarian cancer. TGF-2 was associated with poor OS and PFS from treatment with chemotherapy with platins, Taxol, or a platin+Taxol. However, overexpression of TGF-3 was associated with poor OS from the use of platins and poor PFS of Taxol or a platin+Taxol in women with ovarian carcinoma. Furthermore, the expression of TGF-2 mRNA and protein was higher but only TGF-3 mRNA expression was higher in cancerous tissues than in normal ovarian samples.

CONCLUSION

Higher expression of TGF-2 functioned as a significant predictor of poor prognosis in women with ovarian cancer, especially those with TP53 mutations or who were undergoing chemotherapy with platins, Taxol, or a platin+Taxol.

摘要

目的

探讨转化生长因子-β（TGF-β）亚型在卵巢癌患者预后中的潜在作用。方法：从 Kaplan-Meier 绘线器（KM 绘线器）数据库中检索个体 TGF-β亚型在卵巢癌女性患者中的预后作用。此外，还使用 Oncomine 数据库和免疫组织化学观察 TGF-β亚型在人类卵巢癌和正常卵巢样本中的 mRNA 和蛋白表达。

结果

TGF-β1 和 TGF-β4 与卵巢癌女性的生存结局完全无关。TGF-β2 和 TGF-β3 mRNA 表达增加与不良预后显著相关，尤其是在浆液性、低分化和晚期卵巢癌患者中。TGF-β2 高表达与无进展生存期（PFS）较差相关，而 TGF-β3 与 TP53 突变型卵巢癌患者的总生存期（OS）和 PFS 不良相关。TGF-β2 与含铂、紫杉醇或铂+紫杉醇化疗的不良 OS 和 PFS 相关。然而，TGF-β3 过表达与含铂的不良 OS 和紫杉醇或铂+紫杉醇的不良 PFS 相关。此外，与正常卵巢组织相比，TGF-β2 mRNA 和蛋白表达更高，但只有 TGF-β3 mRNA 表达更高。

结论

TGF-β2 高表达是卵巢癌女性预后不良的显著预测因子，尤其是那些 TP53 突变或接受含铂、紫杉醇或铂+紫杉醇化疗的患者。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c825/7174935/eed78c23d57f/BMRI2020-2170606.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c825/7174935/be6cb0a5ef4e/BMRI2020-2170606.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c825/7174935/35350cf0f0bf/BMRI2020-2170606.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c825/7174935/29a4cecd9520/BMRI2020-2170606.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c825/7174935/1ef3674f0df0/BMRI2020-2170606.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c825/7174935/be9eb0bfe3ea/BMRI2020-2170606.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c825/7174935/eed78c23d57f/BMRI2020-2170606.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c825/7174935/be6cb0a5ef4e/BMRI2020-2170606.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c825/7174935/35350cf0f0bf/BMRI2020-2170606.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c825/7174935/29a4cecd9520/BMRI2020-2170606.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c825/7174935/1ef3674f0df0/BMRI2020-2170606.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c825/7174935/be9eb0bfe3ea/BMRI2020-2170606.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c825/7174935/eed78c23d57f/BMRI2020-2170606.006.jpg

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