Okazaki Satoshi, Otsuka Ikuo, Numata Shusuke, Horai Tadasu, Mouri Kentaro, Boku Shuken, Ohmori Tetsuro, Sora Ichiro, Hishimoto Akitoyo
Department of Psychiatry, Kobe University Graduate School of Medicine, Kobe, Japan.
Department of Psychiatry, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.
NPJ Schizophr. 2019 Feb 27;5(1):4. doi: 10.1038/s41537-019-0072-1.
The accelerated aging hypothesis of schizophrenia (SCZ) has been proposed. DNA methylation profiles were developed for determining "epigenetic age." Here, we assessed intrinsic and extrinsic epigenetic age acceleration (IEAA and EEAA, respectively) in SCZ. We examined two independent cohorts of Japanese ancestry. The first cohort consisted of 80 patients with SCZ under long-term or repeated hospitalization and 40 controls, with the economical DNA pooling technique. The second cohort consisted of 24 medication-free patients with SCZ and 23 controls. Blood of SCZ subjects exhibited decreased EEAA in the first cohort (p = 0.0162), but not in the second cohort. IEAA did not differ in either cohort. We performed replication analyses using publicly available datasets from European ancestry (three blood and one brain datasets). One blood dataset showed increased EEAA in SCZ (p = 0.0228). Overall, our results provide evidence for decreased EEAA in SCZ associated with hospitalization in the Japanese population.
精神分裂症（SCZ）的加速衰老假说已被提出。通过DNA甲基化谱来确定“表观遗传年龄”。在此，我们评估了SCZ患者的内在和外在表观遗传年龄加速（分别为IEAA和EEAA）。我们研究了两个独立的日本血统队列。第一个队列由80名长期或反复住院的SCZ患者和40名对照组成，采用经济的DNA池技术。第二个队列由24名未服药的SCZ患者和23名对照组成。在第一个队列中，SCZ受试者的血液EEAA降低（p = 0.0162），但在第二个队列中未降低。两个队列中的IEAA均无差异。我们使用来自欧洲血统的公开可用数据集（三个血液数据集和一个大脑数据集）进行了重复分析。一个血液数据集显示SCZ患者的EEAA增加（p = 0.0228）。总体而言，我们的结果为日本人群中SCZ患者与住院相关的EEAA降低提供了证据。
