表观遗传学分析证实精神分裂症患者不存在大脑加速老化现象。
Epigenetic analysis confirms no accelerated brain aging in schizophrenia.
作者信息
Voisey Joanne, Lawford Bruce R, Morris C Phillip, Wockner Leesa F, Noble Ernest P, Young Ross McD, Mehta Divya
机构信息
School of Biomedical Sciences, Faculty of Health, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia.
School of Psychology and Counselling, Faculty of Health, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia.
出版信息
NPJ Schizophr. 2017 Sep 4;3(1):26. doi: 10.1038/s41537-017-0026-4.
Epigenetic aging is associated with several biological mechanisms and diseases. We assessed two brain data sets, one small (n = 48) and one large (n = 392), to test epigenetic aging in schizophrenia. DNA methylation age from frontal cortex was significantly correlated with chronological age but no significant differences in DNA methylation age acceleration between schizophrenia cases and controls were observed in both data sets. Our results were consistent with a previous study investigating schizophrenia and epigenetic aging in superior temporal gyrus. Future studies targeting different brain regions and defined cell types are warranted to further investigate accelerated brain aging in schizophrenia.
表观遗传衰老与多种生物学机制和疾病相关。我们评估了两个脑数据集，一个小数据集（n = 48）和一个大数据集（n = 392），以测试精神分裂症中的表观遗传衰老。额叶皮质的DNA甲基化年龄与实际年龄显著相关，但在两个数据集中，精神分裂症病例与对照组之间的DNA甲基化年龄加速均未观察到显著差异。我们的结果与先前一项研究颞上回中精神分裂症和表观遗传衰老的研究一致。有必要开展针对不同脑区和特定细胞类型的未来研究，以进一步探究精神分裂症中的脑衰老加速现象。
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