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声压级动态调节双耳听觉的时间滤波器。

A Temporal Filter for Binaural Hearing Is Dynamically Adjusted by Sound Pressure Level.

机构信息

Department Biology II, Division of Neurobiology, Ludwig-Maximilians-Universität München, Munich, Germany.

Institute of Zoology and Neurobiology, Ruhr-Universität Bochum, Bochum, Germany.

出版信息

Front Neural Circuits. 2019 Feb 13;13:8. doi: 10.3389/fncir.2019.00008. eCollection 2019.

DOI:10.3389/fncir.2019.00008
PMID:30814933
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6381077/
Abstract

In natural environments our auditory system is exposed to multiple and diverse signals of fluctuating amplitudes. Therefore, to detect, localize, and single out individual sounds the auditory system has to process and filter spectral and temporal information from both ears. It is known that the overall sound pressure level affects sensory signal transduction and therefore the temporal response pattern of auditory neurons. We hypothesize that the mammalian binaural system utilizes a dynamic mechanism to adjust the temporal filters in neuronal circuits to different overall sound pressure levels. Previous studies proposed an inhibitory mechanism generated by the reciprocally coupled dorsal nuclei of the lateral lemniscus (DNLL) as a temporal neuronal-network filter that suppresses rapid binaural fluctuations. Here we investigated the consequence of different sound levels on this filter during binaural processing. Our and electrophysiology in Mongolian gerbils shows that the integration of ascending excitation and contralateral inhibition defines the temporal properties of this inhibitory filter. The time course of this filter depends on the synaptic drive, which is modulated by the overall sound pressure level and N-methyl-D-aspartate receptor (NMDAR) signaling. In psychophysical experiments we tested the temporal perception of humans and show that detection and localization of two subsequent tones changes with the sound pressure level consistent with our physiological results. Together our data support the hypothesis that mammals dynamically adjust their time window for sound detection and localization within the binaural system in a sound level dependent manner.

摘要

在自然环境中，我们的听觉系统会接收到多个幅度波动的多样信号。因此，为了检测、定位和分辨单个声音，听觉系统必须处理和过滤来自双耳的频谱和时间信息。已知总声压级会影响感觉信号转导，从而影响听觉神经元的时间响应模式。我们假设哺乳动物的双耳系统利用动态机制来调整神经元回路中的时间滤波器，以适应不同的总声压级。先前的研究提出了一种由外侧丘系背核（DNLL）的相互耦合产生的抑制机制，作为一种抑制快速双耳波动的时间神经元网络滤波器。在这里，我们研究了不同声级对这种滤波器在双耳处理过程中的影响。我们的和电生理学在蒙古沙鼠中的研究表明，上升兴奋和对侧抑制的整合定义了这种抑制滤波器的时间特性。该滤波器的时间过程取决于突触驱动，而突触驱动受总声压级和 N-甲基-D-天冬氨酸受体（NMDAR）信号的调制。在心理物理实验中，我们测试了人类的时间感知能力，并表明两个后续音调的检测和定位随声压级的变化而变化，这与我们的生理结果一致。综上所述，我们的数据支持这样一种假设，即哺乳动物以依赖声级的方式在双耳系统中动态调整其声音检测和定位的时间窗口。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94c6/6381077/d3079c8b02cb/fncir-13-00008-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94c6/6381077/c092f09a5e4f/fncir-13-00008-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94c6/6381077/7c658f54b7c6/fncir-13-00008-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94c6/6381077/185e511ee7e5/fncir-13-00008-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94c6/6381077/45b942d7c803/fncir-13-00008-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94c6/6381077/b55b5ea779ef/fncir-13-00008-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94c6/6381077/d3079c8b02cb/fncir-13-00008-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94c6/6381077/c092f09a5e4f/fncir-13-00008-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94c6/6381077/7c658f54b7c6/fncir-13-00008-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94c6/6381077/185e511ee7e5/fncir-13-00008-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94c6/6381077/45b942d7c803/fncir-13-00008-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94c6/6381077/b55b5ea779ef/fncir-13-00008-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94c6/6381077/d3079c8b02cb/fncir-13-00008-g0006.jpg

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本文引用的文献

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A novel concept for dynamic adjustment of auditory space.一种用于动态调整听觉空间的新方法。
Sci Rep. 2018 May 29;8(1):8335. doi: 10.1038/s41598-018-26690-0.
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Electrogenic N-methyl-D-aspartate receptor signaling enhances binaural responses in the adult brainstem.电致型 N-甲基-D-天冬氨酸受体信号增强成年脑干的双耳反应。
Eur J Neurosci. 2018 Apr;47(7):858-865. doi: 10.1111/ejn.13859. Epub 2018 Feb 21.
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