济州岛浓缩水中含钒的营养培养提取物的抗糖尿病作用。
Antidiabetic effect of an extract of nutricultured containing vanadium from a Jeju water concentrate.
作者信息
Yun Ji-Hyun, Park Sung-Hwan, Choi Goo-Hee, Park In-Jae, Lee Jin-Ha, Lee Ok-Hwan, Kim Jung-Hyon, Seo Yun-Hee, Cho Ju-Hyun
机构信息
Hurum Central Research Institute Co., Ltd., Seogwipo, 63608 Republic of Korea.
2Department of Food Science and Biotechnology, Kangwon National University, Chuncheon, 24341 Republic of Korea.
出版信息
Food Sci Biotechnol. 2018 Aug 3;28(1):209-214. doi: 10.1007/s10068-018-0436-8. eCollection 2019 Feb.
The purpose of this study was to determine the antidiabetic effect of an extract of nutricultured containing vanadium (BECV). The BECV was prepared following nutriculture of with a Jeju water vanadium concentrate for 7 day. The BECV was administered to mice for 8 weeks at different dosages (0.028, 0.14, and 0.7 μg/kg; as vanadium concentration in BECV). After 8 weeks, the BECV results showed mouse blood glucose concentrations to significantly decrease, in a dose-dependent manner, compared with the results for control mice. In addition, the concentrations of triglyceride, total cholesterol, and glycated hemoglobin were significantly lower after 8 weeks of administration of 0.7 μg/kg BECV. Therefore, the BECV may have protective effects against type 2 diabetes.
本研究的目的是确定含钒营养培养提取物（BECV）的抗糖尿病作用。BECV是在以济州岛含钒浓缩水对[具体物质未给出]进行7天营养培养后制备的。将不同剂量（0.028、0.14和0.7μg/kg；以BECV中的钒浓度计）的BECV给予小鼠8周。8周后，BECV的结果显示，与对照小鼠的结果相比，小鼠血糖浓度呈剂量依赖性显著降低。此外，给予0.7μg/kg BECV 8周后，甘油三酯、总胆固醇和糖化血红蛋白的浓度显著降低。因此，BECV可能对2型糖尿病具有保护作用。
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