College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University, 102 Jejudaehakno, Jeju, 63243, Republic of Korea.
Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Mol Biol Rep. 2019 Aug;46(4):4443-4452. doi: 10.1007/s11033-019-04899-0. Epub 2019 Jul 13.
Containing high concentration of vanadium served by the volcanic bedrock, Jeju ground water has long been known for various implicit health benefits including immune-promotion. Exposure to stress has been reported to be associated with immunosuppression such as reducing lymphocyte population or antibody production due to stress hormones. In this study, we aimed at evaluating the effects of Jeju ground water on chronically stressed mice. C57BL/6 mice were subjected to various stressors such as restraint stress, water swimming stress, heat stress, acoustic stress, and Jeju ground water was supplied for 28 days with two different concentrations, S1 (vanadium 15-20 μg/l, pH 8.3) and S2 (vanadium 20-25 μg/l, pH 8.5). Treatment with Jeju ground water increased CD4CD8 or CD4CD8 single-positive thymocytes. It also increased the proliferation of splenocytes and the populations of CD4 T cells, CD45R/B220 B cells, CD11b macrophages or Gr-1 granulocytes in spleen. In addition, the production of IgG was increased in chronically stressed mice by treatment with Jeju ground water. These results suggest vanadium-rich Jeju ground water may be helpful in T cell development in thymus and immune cell proliferation and its function in spleen against chronic stress.
济州地下水含有高浓度的钒，来源于火山基岩，长期以来一直因其具有各种潜在的健康益处而闻名，包括促进免疫。据报道，暴露于应激下与免疫抑制有关，如由于应激激素导致淋巴细胞群体或抗体产生减少。在这项研究中，我们旨在评估济州地下水对慢性应激小鼠的影响。C57BL/6 小鼠受到各种应激源的影响，如束缚应激、水游泳应激、热应激、声应激，并在 28 天内以两种不同浓度（S1：钒 15-20μg/l，pH8.3 和 S2：钒 20-25μg/l，pH8.5）供应济州地下水。济州地下水的处理增加了 CD4CD8 或 CD4CD8 单阳性胸腺细胞。它还增加了脾细胞增殖和 CD4 T 细胞、CD45R/B220 B 细胞、CD11b 巨噬细胞或 Gr-1 粒细胞的群体。此外，济州地下水的处理增加了慢性应激小鼠 IgG 的产生。这些结果表明，富含钒的济州地下水可能有助于胸腺中的 T 细胞发育以及脾中免疫细胞的增殖及其功能抵抗慢性应激。
