金属 3D 打印用钛粉涂层：一种钴铬合金植入物的新型涂层技术。
Titanium Powder Coating Using Metal 3D Printing: A Novel Coating Technology for Cobalt-Chromium Alloy Implants.
机构信息
1Department of Orthopaedic Surgery, St. Paul's Hospital, College of Medicine, The Catholic University of Korea, 180 Wangsan-ro, Dongdaemun-gu, Seoul, South Korea.
2Department of Orthopaedic Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, South Korea.
出版信息
Tissue Eng Regen Med. 2019 Jan 4;16(1):11-18. doi: 10.1007/s13770-018-0168-0. eCollection 2019 Feb.
BACKGROUND
Three-dimensional (3D) printing with a direct metal fabrication (DMF) technology has been innovatively introduced in the field of surface treatment of prostheses. The purpose of this study was to determine whether such modifications on the surface of cobalt-chromium (CoCr) alloy by titanium powder coating using DMF improves the osseointegration ability of CoCr alloy.
METHODS
We compared the and ability of cells to adhere to DMF-coated CoCr alloy with machining. Biological and morphological responses to human osteoblast cell lines were examined by measuring cell proliferation rate and observing expression of actin filament. For in vivo study, we inserted different specimens in each medulla of the distal femurs of rabbit. After 3 months, the distal femurs were harvested, and a push-out test and histomorphometric analyses were performed.
RESULTS
The cell proliferation rate and cell adhesion in the DMF group were higher compared with those in the machined group. Human osteoblast cells on the DMF-coated surface were more strongly adhered and well-proliferated compared with those on the other surface. In the test, there was a significant difference in the ultimate shear strength between the DMF and machined groups (2.49 MPa vs. 0.87 MPa, respectively, = 0.001). In the histomorphometric analysis, there was a significant difference in the mean bone-to-implant contact percentages between the DMF and machined groups (72.3 ± 6.2% vs. 47.6 ± 6.9%, respectively, < 0.001).
CONCLUSION
Titanium coating of CoCr alloy with 3D metal printing provides optimal surface characteristics and a good biological surface both and .
背景
三维（3D）打印与直接金属制造（DMF）技术已创新性地引入到假体表面处理领域。本研究旨在确定通过 DMF 用钛粉涂层对钴铬（CoCr）合金表面进行的这种改性是否能提高 CoCr 合金的骨整合能力。
方法
我们比较了 DMF 涂层 CoCr 合金与机械加工的细胞黏附性和 能力。通过测量细胞增殖率和观察肌动蛋白丝的表达来检测对人成骨细胞系的生物学和形态学反应。对于体内研究，我们将不同的标本插入兔股骨远端的每个髓腔中。3 个月后，取出远端股骨，并进行推出试验和组织形态计量学分析。
结果
与机械加工组相比，DMF 组的细胞增殖率和细胞黏附性更高。与其他表面相比，DMF 涂层表面上的人成骨细胞黏附性更强，增殖更好。在 试验中，DMF 组和机械加工组的最终抗剪强度有显著差异（分别为 2.49 MPa 和 0.87 MPa， = 0.001）。在组织形态计量学分析中，DMF 组和机械加工组的平均骨-种植体接触百分比有显著差异（分别为 72.3 ± 6.2%和 47.6 ± 6.9%， < 0.001）。
结论
3D 金属打印用 CoCr 合金的钛涂层提供了最佳的表面特性和良好的生物表面，无论是 还是 。
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