腕管综合征（手掌研究）中皮质类固醇注射或手术治疗反应的预后因素：一项前瞻性多中心队列研究。
Prognostic factors for response to treatment by corticosteroid injection or surgery in carpal tunnel syndrome (palms study): A prospective multicenter cohort study.
机构信息
School of Health Sciences, Faculty of Medicine and Health Sciences, University of East Anglia, Norwich, NR4 7TJ, United Kingdom.
Norwich Medical School, University of East Anglia, Norwich, United Kingdom.
出版信息
Muscle Nerve. 2019 Jul;60(1):32-40. doi: 10.1002/mus.26459. Epub 2019 Mar 24.
INTRODUCTION
Studies of prognosis for surgery and corticosteroid injection for carpal tunnel syndrome (CTS) have considered only a limited range of explanatory variables for outcome.
METHODS
Data were prospectively collected on patient-reported symptoms, physical and psychological functioning, comorbidity, and quality of life at baseline and every 6 months for up to 2 years. Outcomes were patient-rated change over a 6-month period and symptom-severity score at 18 months.
RESULTS
In total, 754 patients with CTS completed baseline questionnaires, and 626 (83%) completed follow-up to 18 months. Multivariable modeling identified, independent of symptom severity at outset, higher health utility, fewer comorbidities, and lower anxiety as significant predictors of better outcome from surgery. In patients treated by steroid injection, independent of symptom severity at outset, shorter duration of symptoms and having no prior injection were significant predictors of better outcome.
DISCUSSION
These multivariable models of outcome may inform shared decision making about treatment for CTS. Muscle Nerve, 2019.
简介
研究手术和皮质类固醇注射治疗腕管综合征（CTS）的预后时，仅考虑了有限范围的预后结果的解释变量。
方法
在基线和最多 2 年内，每 6 个月收集一次患者报告的症状、身体和心理功能、合并症和生活质量数据。结果为患者在 6 个月内的变化和 18 个月时的症状严重程度评分。
结果
共有 754 例 CTS 患者完成了基线问卷调查，其中 626 例（83%）完成了 18 个月的随访。多变量模型确定，在开始时症状严重程度之外，较高的健康效用、较少的合并症和较低的焦虑是手术预后较好的重要预测因素。对于接受类固醇注射治疗的患者，除开始时的症状严重程度外，症状持续时间较短和无既往注射也是预后较好的重要预测因素。
讨论
这些预后的多变量模型可能有助于就 CTS 的治疗做出共同决策。肌肉神经，2019 年。
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