脂联素及脂联素受体1水平对2型糖尿病患者大血管并发症的影响
The Effects of Adiponectin and Adiponectin Receptor 1 Levels on Macrovascular Complications Among Patients with Type 2 Diabetes Mellitus.
作者信息
Su Na, Zhao Nairui, Wang Guangya, Wang Linxia, Zhang Yunna, Li Ruijie, Liu Ying, Yang Xinxin, Li Cuiliu, Hou Mingming
机构信息
Department of Second Endocrinology, Cangzhou Central Hospital, Cangzhou, China,
Department of Second Endocrinology, Cangzhou Central Hospital, Cangzhou, China.
出版信息
Cell Physiol Biochem. 2019;52(2):225-231. doi: 10.33594/000000016. Epub 2019 Feb 28.
BACKGROUND/AIMS: The present study aimed to investigate the serum levels of adiponectin (APN) and adiponectin receptor 1 (AdipoR1) in patients with type 2 diabetes mellitus (T2DM) combined with macrovascular complications (MVC), as well as their correlation with clinical parameters.
METHODS
A total of 60 T2DM patients were divided into 2 groups according to the presence of MVC: T2DM + MVC group (n=30) and T2DM group (n=30). Additionally, 30 healthy people were selected as control group (NC group). Clinical data and biological parameters were detected and recorded. T test was performed to compare the differences between two groups, and the results were corrected using Bonferroni method. Meanwhile, the correlation analysis and multiple stepwise regression analysis were used to analyze the association of APN and AdipoR1 with clinical factors.
RESULTS
The levels of APN and AdipoR1 were significantly decreased in T2DM group and T2DM + MVC group compared with NC group, with the lowest value in T2DM + MVC group (all P<0.01). Serum APN levels were positively correlated with FINS and TG (r = 0.412, 0.316, respectively; both P<0.05), and negatively correlated with SBP, DBP and LDL-C (r = -0.292, -0.383, -0.334, respectively; all P<0.05). Serum levels of AdipoR1 were positively correlated with APN (r = 0.726, P<0.01), and negatively correlated with BMI, SBP, DBP, FBG, TC and LDL-C (r = -0.440, -0.446, -0.374, -0.444, -0.344, -0.709, respectively; all P<0.01).
CONCLUSION
Serum levels of APN and AdipoR1 are significantly lower in T2DM group and T2DM + MVC group, showing lowest value in T2DM + MVC group. APN and AdipoR1 levels may influence glucose and lipid metabolism in T2DM patients.
背景/目的：本研究旨在探讨2型糖尿病（T2DM）合并大血管并发症（MVC）患者血清脂联素（APN）和脂联素受体1（AdipoR1）水平，以及它们与临床参数的相关性。
方法
将60例T2DM患者根据是否存在MVC分为2组：T2DM + MVC组（n = 30）和T2DM组（n = 30）。另外，选取30例健康人作为对照组（NC组）。检测并记录临床资料和生物学参数。采用t检验比较两组间差异，结果用Bonferroni法校正。同时，采用相关性分析和多元逐步回归分析来分析APN和AdipoR1与临床因素的关联。
结果
与NC组相比，T2DM组和T2DM + MVC组的APN和AdipoR1水平显著降低，T2DM + MVC组最低（均P < 0.01）。血清APN水平与空腹胰岛素（FINS）和甘油三酯（TG）呈正相关（r分别为0.412、0.316；均P < 0.05），与收缩压（SBP）、舒张压（DBP）和低密度脂蛋白胆固醇（LDL-C）呈负相关（r分别为 - 0.292、 - 0.383、 - 0.334；均P < 0.05）。血清AdipoR1水平与APN呈正相关（r = 0.726，P < 0.01），与体重指数（BMI）、SBP、DBP、空腹血糖（FBG）、总胆固醇（TC）和LDL-C呈负相关（r分别为 - 0.440、 - 0.446、 - 0.374、 - 0.444、 - 0.344、 - 0.709；均P < 0.01）。
结论
T2DM组和T2DM + MVC组血清APN和AdipoR1水平显著降低，T2DM + MVC组最低。APN和AdipoR1水平可能影响T2DM患者的糖脂代谢。
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