Kitagawa H, Kurahashi K, Fujiwara M
J Pharmacol Exp Ther. 1986 Mar;236(3):784-8.
The correlation between acid secretion and mucosal blood flow in the gastric mucosa after administration of reserpine to rats was determined in an attempt to define the etiology of reserpine-induced gastric erosions. Although gastric acid output was increased gradually by administration of reserpine, mucosal blood flow was not significantly affected. The increase in acid output induced by reserpine was completely prevented by pretreatment with atropine. Reserpine-induced increase in acid secretion may have been mediated by the vagus nerves, probably as a result of central and/or peripheral diminution in noradrenergic inhibitory mechanisms. The dissociation between mucosal blood flow and acid secretion, resulting in a relative ischemic state in the gastric mucosa, may have occurred in part from reduced cardiac function after treatment with reserpine. Vagal stimulation induced a parallel increase in both acid secretion and mucosal blood flow in control rats. 6-Hydroxydopamine-induced sympathectomy did not increase mucosal blood flow to a degree corresponding to the increase in acid output by vagal stimulation. In animals treated with 6-hydroxydopamine, gastric erosions occurred. We conclude that reserpine increases acid output but without a parallel increase in the mucosal blood flow and that the erosions which occur are probably due to the relative ischemic state of the gastric mucosa.
为了明确利血平诱发胃糜烂的病因，对给予利血平后的大鼠胃黏膜酸分泌与黏膜血流之间的相关性进行了测定。尽管给予利血平后胃酸分泌逐渐增加，但黏膜血流并未受到显著影响。利血平诱发的酸分泌增加可被阿托品预处理完全阻止。利血平诱发的酸分泌增加可能是由迷走神经介导的，这可能是去甲肾上腺素能抑制机制在中枢和/或外周减弱的结果。黏膜血流与酸分泌之间的分离，导致胃黏膜处于相对缺血状态，这可能部分是由于利血平治疗后心脏功能降低所致。在对照大鼠中，迷走神经刺激可使酸分泌和黏膜血流同时平行增加。6-羟基多巴胺诱发的交感神经切除术并未使黏膜血流增加到与迷走神经刺激引起的酸分泌增加程度相对应的水平。在用6-羟基多巴胺处理的动物中，出现了胃糜烂。我们得出结论，利血平增加酸分泌，但黏膜血流并未平行增加，且发生的糜烂可能是由于胃黏膜的相对缺血状态所致。
