Yokotani K, Muramatsu I, Fujiwara M, Osumi Y
J Pharmacol Exp Ther. 1983 Feb;224(2):436-42.
Effects of the sympathoadrenal system on vagally induced increases in gastric acid secretion and mucosal blood flow (MBF) were studied in anesthetized, gastric fistula rats. Greater splanchnic nerve stimulation reduced significantly both the gastric acid secretion and MBF. Stimulation of the splanchnic postganglionic nerve reduced to a greater extent the acid secretion than the MBF, while stimulation of the adrenal branch reduced both the acid secretion and MBF. Infusion of epinephrine also reduced both the acid secretion and MBF, but the reduction of MBF was the more prominent. Phentolamine, but not propranolol and alprenolol, reduced the inhibitory effects on both gastric functions of the splanchnic postganglionic nerve stimulation and adrenal branch stimulation or epinephrine infusion. These results suggest that catecholamines released from the splanchnic postganglionic nerve terminals inhibit gastric acid secretion through alpha adrenergic receptors in the stomach, independent of MBF, and that circulating catecholamines released from the adrenal medulla inhibit both the acid secretion and MBF through alpha adrenergic receptors in the stomach. The inhibition by greater splanchnic nerve stimulation is probably the sum of the effects induced by catecholamines released from the splanchnic postganglionic nerve terminals and from the adrenal medulla.
在麻醉的胃瘘大鼠中研究了交感肾上腺系统对迷走神经诱导的胃酸分泌增加和黏膜血流量（MBF）的影响。更强的内脏神经刺激显著降低了胃酸分泌和MBF。刺激内脏神经节后神经对胃酸分泌的降低程度大于对MBF的降低程度，而刺激肾上腺分支则同时降低了胃酸分泌和MBF。输注肾上腺素也降低了胃酸分泌和MBF，但对MBF的降低更为显著。酚妥拉明而非普萘洛尔和阿普洛尔可减轻内脏神经节后神经刺激、肾上腺分支刺激或肾上腺素输注对两种胃功能的抑制作用。这些结果表明，从内脏神经节后神经末梢释放的儿茶酚胺通过胃中的α肾上腺素能受体抑制胃酸分泌，与MBF无关，并且从肾上腺髓质释放的循环儿茶酚胺通过胃中的α肾上腺素能受体同时抑制胃酸分泌和MBF。更强的内脏神经刺激所产生的抑制作用可能是内脏神经节后神经末梢和肾上腺髓质释放的儿茶酚胺所诱导效应的总和。
