实验性脊髓损伤后脊髓中促甲状腺激素释放激素免疫反应性的变化。
Changes in TRH immunoreactivity in spinal cord after experimental spinal injury.
作者信息
Faden A I, Hill T G, Kubek M J
出版信息
Neuropeptides. 1986 Jan;7(1):11-8. doi: 10.1016/0143-4179(86)90073-9.
PMID:3081828
Abstract
Concentrations of immunoreactive TRH (TRH-ir) in rat spinal cord were examined after traumatic injury. TRH-ir was significantly increased at the injury site (thoracic region) and rostral areas (cervical region), and significantly decreased below the injury site. Changes were delayed and time-dependent. Since TRH may serve as an excitatory neurotransmitter within the spinal cord, these changes may contribute to the functional alterations observed after spinal injury.
摘要
在创伤性损伤后检测了大鼠脊髓中免疫反应性促甲状腺激素释放激素（TRH-ir）的浓度。TRH-ir在损伤部位（胸段）和损伤部位上方区域（颈段）显著增加，而在损伤部位下方则显著降低。这些变化出现延迟且具有时间依赖性。由于TRH可能在脊髓内作为一种兴奋性神经递质，这些变化可能导致脊髓损伤后观察到的功能改变。
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