Kveton J F, Brackmann D E, Glasscock M E, House W F, Hitselberger W E
Otolaryngol Head Neck Surg. 1986 Jan;94(1):23-32. doi: 10.1177/019459988609400104.
Chondrosarcoma of the skull base is an uncommon neoplasm that comprises 0.15% of all intracranial tumors and 6% of skull base lesions. Compression of vital neurologic structures by tumor expansion as well as the histologic characteristics contribute to the malignant potential of these neoplasms. Tumor recurrence has been associated with incomplete resection in this traditionally surgically inaccessible region. This review of five cases of chondrosarcoma of the skull base examines the surgical approaches to resection in a chronologic fashion to emphasize that total gross resection of these lesions has become possible through the evolution of lateral skull base techniques. The difficulty in pathologic diagnosis and the efficacy of postoperative radiotherapy in enhancing survival are also addressed.
颅底软骨肉瘤是一种罕见的肿瘤，占所有颅内肿瘤的0.15%，占颅底病变的6%。肿瘤扩张对重要神经结构的压迫以及组织学特征导致了这些肿瘤的恶性潜能。在这个传统上手术难以触及的区域，肿瘤复发与切除不完全有关。本文回顾了5例颅底软骨肉瘤病例，按时间顺序审视了切除手术的入路，以强调通过侧颅底技术的发展，这些病变的全大体切除已成为可能。文中还讨论了病理诊断的困难以及术后放疗在提高生存率方面的疗效。
