Gore Mitchell R
Otolaryngology - Head and Neck Surgery, State University of New York Upstate Medical University, Syracuse, USA.
Cureus. 2022 Nov 28;14(11):e31973. doi: 10.7759/cureus.31973. eCollection 2022 Nov.
Temporal bone malignancies are relatively uncommon tumors. Their location adjacent to vital structures such as the carotid artery, jugular vein, otic capsule, and temporal lobe can make their treatment potentially challenging. The purpose of this study was to compare outcomes in temporal bone malignancies obtained via pooled literature data. The study sought to examine factors affecting survival in temporal bone malignancies based on the studies in the existing published literature. A systematic search was conducted on the PubMed (Medline), Embase, and Google Scholar databases to identify relevant studies from 1951 to 2022 that described the treatment of temporal bone malignancies. Articles that fulfilled the inclusion criteria were assessed and analyzed by the author. The literature search identified 5875 case series and case reports, and 161 of them contained sufficient data to be included in the pooled data analysis, involving a total of 825 patients. Multivariate analysis of the pooled literature data showed that overall stage, presence of facial palsy, and surgical margin status significantly affected overall survival (OS), while overall stage and presence of facial palsy significantly affected disease-free survival (DFS). To summarize, this study examined pooled survival data on demographics, treatment, and survival of patients with temporal bone malignancies utilizing an extensive literature-based pooled data meta-analysis. Overall stage, facial nerve status, and surgical margin status appeared to most strongly affect survival in patients with temporal bone malignancies.
颞骨恶性肿瘤是相对罕见的肿瘤。它们毗邻颈动脉、颈静脉、听囊和颞叶等重要结构，这使得其治疗颇具挑战性。本研究的目的是通过汇总文献数据比较颞骨恶性肿瘤的治疗结果。该研究旨在根据现有已发表文献中的研究，探讨影响颞骨恶性肿瘤患者生存的因素。我们对PubMed（Medline）、Embase和谷歌学术数据库进行了系统检索，以确定1951年至2022年期间描述颞骨恶性肿瘤治疗的相关研究。符合纳入标准的文章由作者进行评估和分析。文献检索共识别出5875个病例系列和病例报告，其中161个包含足够的数据可纳入汇总数据分析，涉及总共825例患者。对汇总文献数据的多变量分析表明，总体分期、面神经麻痹的存在以及手术切缘状态显著影响总生存期（OS），而总体分期和面神经麻痹的存在显著影响无病生存期（DFS）。总之，本研究利用广泛的基于文献的汇总数据荟萃分析，研究了颞骨恶性肿瘤患者的人口统计学、治疗和生存的汇总生存数据。总体分期、面神经状态和手术切缘状态似乎对颞骨恶性肿瘤患者的生存影响最为强烈。
