Yin X R, Liu Z H, Hou J L
Institute of Hepatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Zhonghua Gan Zang Bing Za Zhi. 2019 Feb 20;27(2):81-84. doi: 10.3760/cma.j.issn.1007-3418.2019.02.001.
The World Health Organization(WHO)has set the goal to eliminate viral hepatitis as a public health threat by 2030, and the key to achieve this ambitious goal lies on the standardized and precise management of pregnant women and their infants by effectively blocking mother-to-child transmission (MTCT) of hepatitis B virus (HBV). Standardized management includes screening and antiviral intervention during pregnancy, infant immunization, and evaluation of immune effect, breastfeeding and mode of delivery. The results of randomized controlled clinical trials and real-world data have confirmed that the comprehensive prevention strategy based on combined immune prophylaxis of neonates can effectively block MTCT of HBV. It is one of the key links to eliminate viral hepatitis in our country, and to formulate a new strategy in line with the public health needs at home and abroad and thereby promote the implementation and application of standardized management process to improve the public's awareness of the disease.
世界卫生组织（WHO）已设定目标，到2030年消除病毒性肝炎对公共卫生的威胁，而实现这一宏伟目标的关键在于通过有效阻断乙型肝炎病毒（HBV）的母婴传播（MTCT），对孕妇及其婴儿进行标准化和精准管理。标准化管理包括孕期筛查与抗病毒干预、婴儿免疫接种以及免疫效果评估、母乳喂养和分娩方式。随机对照临床试验和真实世界数据的结果证实，基于新生儿联合免疫预防的综合预防策略可有效阻断HBV的MTCT。这是我国消除病毒性肝炎的关键环节之一，也是制定符合国内外公共卫生需求的新策略，进而推动标准化管理流程的实施与应用、提高公众对该疾病认识的关键环节之一。
