Department of Surgical Oncology, Medical College of Wisconsin, Milwaukee, WI.
Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI.
Clin Breast Cancer. 2019 Jun;19(3):157-164. doi: 10.1016/j.clbc.2019.01.007. Epub 2019 Jan 31.
No clear standard treatment guidelines exist for older women with breast cancer. In this study we aimed to examine the practice patterns and treatment outcomes of women ≥80 years old with invasive breast cancer. A retrospective chart review at a single academic institution was performed of 124 women diagnosed with stage I to III invasive breast cancer aged ≥80 years between 2005 and 2014. Median age of diagnosis was 84 years. Fifty-nine of the cancers (48%) were detected using mammography. One hundred twelve patients (90%) underwent surgery. There was no difference in comorbidities between the surgical and nonsurgical group (P = .800). In multivariate analysis, age was predictive of receiving surgery (P < .001). Overall survival probability was higher for those who received hormonal therapy (P = .002), radiation therapy (P = .041), and those with lower-stage tumors (P = .018). Surgery was not predictive of survival. It is important to consider comorbidities, complications and, longevity when determining whether elderly women diagnosed with breast cancer benefit from surgery.
对于患有乳腺癌的老年女性，目前尚无明确的标准治疗指南。本研究旨在探讨≥80 岁患有浸润性乳腺癌的女性的治疗模式和治疗效果。对一家学术机构在 2005 年至 2014 年间诊断为Ⅰ至Ⅲ期浸润性乳腺癌且年龄≥80 岁的 124 名女性进行回顾性图表审查。诊断时的中位年龄为 84 岁。59 例癌症（48%）通过乳房 X 线照相术检测到。112 名患者（90%）接受了手术。手术组和非手术组的合并症无差异（P=.800）。多变量分析显示，年龄是接受手术的预测因素（P<.001）。接受激素治疗（P=.002）、放射治疗（P=.041）和肿瘤分期较低的患者（P=.018）的总生存率更高。手术与生存无关。在确定诊断为乳腺癌的老年女性是否受益于手术时，需要考虑合并症、并发症和寿命。
