Bertolo Aaron, Rosso Christopher, Voutsadakis Ioannis A
St. George University School of Medicine, Grenada.
Algoma University, Sault Ste. Marie, Ontario, Canada.
Eur J Breast Health. 2020 May 21;16(3):208-212. doi: 10.5152/ejbh.2020.5659. eCollection 2020 Jul.
Breast cancer is the most common cancer in women and one in ten patients affected are over age 80. However, this age group is mostly excluded from clinical trials and data to inform their care is sparse.
Medical records of all patients aged 80 years-old and older diagnosed and treated for breast cancer in a single center over a six-year period were retrospectively reviewed. A cohort of patients aged 65 to 75 treated for breast cancer at the same center during the same period was also reviewed for comparison.
Patients in the 80 and over age group were commonly diagnosed with stage II or III disease (39.2%) compared to younger patients who were diagnosed more commonly (61.6%) with stage I disease. Sub-types of breast cancer had a similar representation in the two groups. Hormonal therapy was used equally in the two groups, but significantly fewer patients in the 80 and over age group had radiation therapy and chemotherapy as part of their treatment. Despite these differences, recurrence rates were not significantly different between the two groups.
Individualized treatments taking into consideration the patient's general status, comorbidities and life expectancy are feasible in the older breast cancer population and result in outcomes similar to those of younger patients in the short and intermediate terms.
乳腺癌是女性中最常见的癌症，每十名患者中就有一名年龄超过80岁。然而，这个年龄组大多被排除在临床试验之外，用于指导其治疗的数据也很稀少。
回顾性分析了一个中心在六年期间诊断和治疗的所有80岁及以上乳腺癌患者的病历。同时也回顾了同期在同一中心接受乳腺癌治疗的65至75岁患者队列，以作比较。
80岁及以上年龄组的患者通常被诊断为II期或III期疾病（39.2%），而较年轻患者更常被诊断为I期疾病（61.6%）。两组乳腺癌亚型的分布相似。两组使用激素治疗的情况相同，但80岁及以上年龄组作为治疗一部分接受放疗和化疗的患者明显较少。尽管存在这些差异，但两组的复发率并无显著差异。
考虑患者的一般状况、合并症和预期寿命的个体化治疗在老年乳腺癌患者中是可行的，并且在短期和中期内产生的结果与年轻患者相似。
