Department of Pediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.
Department of Pediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India. Correspondence to: Dr Rameshkumar R, Associate Professor, Division of Pediatric Critical care, Department of Pediatrics, (JIPMER), Puducherry 605 006, India.
Indian Pediatr. 2019 Feb 15;56(2):126-129.
To find the strength of agreement between point-of-care and serum b-hydroxybutyrate.
236 paired samples (capillary b-hydroxybutyrate by a point of care device and serum b-hydroxybutyrate by colorimetric enzymatic estimation) samples were collected from 26 children aged <13 years admitted with diabetic ketoacidosis. Inborn errors of metabolism and septic shock were excluded.
Capillary b-hydroxybutyrate showed excellent agreement with serum â-hydroxybutyrate with mean (SD) bias of 0.027 (0.78); 95% limit of agreement -1.51, 1.56 and intraclass correlation 96.1% (95%CI 95%-97%, P<0.001). An increase in the bias noted for value above 5 mmol/L (P<0.001) (serum measurements were higher than capillary point-of-care measure-ments). Capillary â-hydroxybutyrate correlated significantly with blood pH, anion gap,bicarbonate and carbon dioxide levels on blood gas analysis (P<0.05).
Capillary b-hydroxybutyrate estimation is a valid method for monitoring of ketonemia in pediatric diabetic ketoacidosis.
寻找即时检测（point-of-care）与血清β-羟丁酸之间的一致性强度。
从 26 名年龄<13 岁、因糖尿病酮症酸中毒入院的儿童中采集了 236 对（即时检测设备检测的毛细血管β-羟丁酸和比色酶法检测的血清β-羟丁酸）样本。排除了先天性代谢错误和感染性休克。
毛细血管β-羟丁酸与血清β-羟丁酸具有极好的一致性，平均（SD）偏差为 0.027（0.78）；95%一致性界限-1.51，1.56 和组内相关系数 96.1%（95%CI 95%-97%，P<0.001）。在 5 mmol/L 以上的数值上，偏差增加（P<0.001）（血清测量值高于毛细血管即时检测测量值）。毛细血管β-羟丁酸与血气分析中的血 pH 值、阴离子间隙、碳酸氢盐和二氧化碳水平显著相关（P<0.05）。
毛细血管β-羟丁酸估测是监测儿童糖尿病酮症酸中毒酮血症的有效方法。
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