Institute of Sports Medicine and Health, Chengdu Sport Institute, Chengdu, 610041, China.
School of Sports Medicine and Health, Chengdu Sport Institute, Chengdu, 610041, China.
J Cardiovasc Transl Res. 2019 Oct;12(5):404-414. doi: 10.1007/s12265-019-09875-4. Epub 2019 Feb 28.
Diastolic dysfunction is a common complication that occurs early in diabetes mellitus. Titin and collagen are two important regulators of myocardial passive tension, which contributes to diabetic myocardial diastolic dysfunction. Exercise therapy significantly improves the impaired diabetic cardiac function, but its benefits appear to depend on the type of exercise used. We investigated the effect of aerobic and resistance exercise on cardiac diastolic function in diabetic rats induced by high-fat diet combined with low-dose streptozotocin injection. Interestingly, although resistance training had a more pronounced effect on blood glucose control than did aerobic training in type 2 diabetic rats, improvements in cardiac diastolic parameters benefited more from aerobic training. Moreover, aerobic exercise did significantly increase the expression levels of titin and decrease collagen I, TGFβ1 expression level. In summary, out data suggest that aerobic exercise may improve diabetic cardiac function through changes in titin-dependent myocardial stiffness rather than collagen-dependent interstitial fibrosis.
舒张功能障碍是糖尿病早期常见的并发症。肌联蛋白和胶原蛋白是心肌被动张力的两个重要调节因子，有助于糖尿病性心肌舒张功能障碍。运动疗法可显著改善受损的糖尿病心功能，但益处似乎取决于所使用的运动类型。我们研究了高脂饮食联合小剂量链脲佐菌素注射诱导的糖尿病大鼠进行有氧和抗阻运动对心脏舒张功能的影响。有趣的是，尽管在 2 型糖尿病大鼠中，抗阻训练对血糖控制的影响比有氧训练更为显著，但心脏舒张参数的改善更受益于有氧训练。此外，有氧运动显著增加了肌联蛋白的表达水平，降低了胶原 I 和 TGFβ1 的表达水平。综上所述，我们的数据表明，有氧运动可能通过改变依赖肌联蛋白的心肌僵硬度而不是依赖于胶原的间质纤维化来改善糖尿病性心功能。
