Ofosu M D, Saunders D A, Dunston G M, Castro O, Alarif L
Am J Hematol. 1986 May;22(1):27-33. doi: 10.1002/ajh.2830220105.
This study evaluates autoantibody production in sickle cell disease patients and determines whether genes in the major histocompatibility complex are associated with autoantibody responses. Rheumatoid factor was significantly increased for both male and female patients and was less prevalent in highly transfused patients. Significant increases were also detected in the incidences of antinuclear antibody for females and antismooth muscle antibody for males. Low incidence of antinuclear antibody was significantly associated with HLA-DR3. Significant associations were also found between the incidence of antinuclear antibody and both HLA-A28 and B15.
本研究评估镰状细胞病患者自身抗体的产生情况，并确定主要组织相容性复合体中的基因是否与自身抗体反应相关。男性和女性患者的类风湿因子均显著升高，且在大量输血的患者中患病率较低。女性抗核抗体和男性抗平滑肌抗体的发生率也显著增加。抗核抗体低发生率与HLA - DR3显著相关。抗核抗体发生率与HLA - A28和B15之间也发现了显著关联。
