Bell D A, Alspaugh M A
J Rheumatol. 1984 Jun;11(3):277-81.
A search was made for the presence of antibody to the rheumatoid arthritis (RA) associated nuclear antigen (RANA) in the sera of 57 affected and unaffected members of 10 families with multiple members affected with RA. While anti-RANA was frequently observed among the seropositive affected individuals with definite or classical RA (60%), it was less frequently observed among those family members who had incompletely expressed disease, and rarely among normal close family members including those sharing haplotypes with the affected index case. An HLA haplotype containing B8, DR3 was more frequently seen among anti-RANA positive (61%) than anti-RANA negative (44%) RA patients. These data do not support a primary early role for the Epstein-Barr virus related antigen RANA in the etiology of RA. They may indicate a possible influence of the complete haplotype HLA-B8, DR3 on the expression of anti-RANA in established RA.
对10个有多例类风湿关节炎（RA）患者的家庭中57名患病和未患病成员的血清进行检测，以查找抗类风湿关节炎相关核抗原（RANA）的抗体。在血清学阳性的确诊或典型RA患者中，抗RANA抗体常见（60%），而在疾病表现不完全的家庭成员中较少见，在正常的近亲家庭成员中，包括与患病先证者共享单倍型的成员中则罕见。在抗RANA阳性的RA患者中（61%），含有B8、DR3的HLA单倍型比抗RANA阴性的RA患者（44%）更常见。这些数据不支持爱泼斯坦-巴尔病毒相关抗原RANA在RA病因学中起主要早期作用。它们可能表明完整的HLA-B8、DR3单倍型对已确诊RA患者抗RANA表达可能有影响。
