Departamento de Biomedicina Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Ciudad de México, México.
J Leukoc Biol. 2019 May;105(5):973-981. doi: 10.1002/JLB.1MR0918-350RRR. Epub 2019 Mar 1.
Connections established between cytoskeleton and plasma membrane are essential in cellular processes such as cell migration, vesicular trafficking, and cytokinesis. Class I myosins are motor proteins linking the actin-cytoskeleton with membrane phospholipids. Previous studies have implicated these molecules in cell functions including endocytosis, exocytosis, release of extracellular vesicles and the regulation of cell shape and membrane elasticity. In immune cells, those proteins also are involved in the formation and maintenance of immunological synapse-related signaling. Thus, these proteins are master regulators of actin cytoskeleton dynamics in different scenarios. Although the localization of class I myosins has been described in vertebrates, their functions, regulation, and mechanical properties are not very well understood. In this review, we focused on and summarized the current understanding of class I myosins in vertebrates with particular emphasis in leukocytes.
细胞骨架与质膜之间的连接对于细胞迁移、囊泡运输和胞质分裂等细胞过程至关重要。I 类肌球蛋白是将肌动蛋白细胞骨架与膜磷脂连接起来的运动蛋白。先前的研究表明这些分子参与了细胞功能，包括内吞作用、胞吐作用、细胞外囊泡的释放以及细胞形状和膜弹性的调节。在免疫细胞中，这些蛋白质也参与免疫突触相关信号的形成和维持。因此，这些蛋白质是不同情况下肌动蛋白细胞骨架动力学的主要调节剂。尽管已经描述了脊椎动物中 I 类肌球蛋白的定位，但它们的功能、调节和机械特性还不是很清楚。在这篇综述中，我们重点总结了目前对脊椎动物 I 类肌球蛋白的理解，特别强调了白细胞中的肌球蛋白。
