Dyleva Yu A, Gruzdeva O V, Akbasheva O E, Uchasova E G, Barbarash O L
The research institute of complex problems of cardio-vascular diseases, 650002, Kemerovo, Russia.
The Kemerovskii state medical university of Minzdrav of Russia, 650029, Kemerovo, Russia.
Klin Lab Diagn. 2017;62(10):599-605. doi: 10.18821/0869-2084-2017-62-10-599-605.
The ST2 is a member of family of receptors of interleukin I (IL-I) and consists of two isoforms: a trans-membrane of cellular one (ST2L) and soluble or circulating one (sST2). The ST2 is a receptor of IL-33 that represents IL-I like cytokine. The IL-33 manifests its cellular functions binding receptor complex consisted of accessory protein ST2L and IL-IR. The system IL-33/ST2 is activated in cardiomyocytes and fibroblasts in response to mechanical irritation or damage. It was demonstrated that interaction between IL-33 and ST2L is a cardioprotective one. The experimental models were used to demonstrate decreasing of myocardium fibrosis, prevention of development of hypertrophy of cardiomyocytes, decreasing of apoptosis and amelioration of functional capacity of myocardium at interaction of IL-33 and ST2L. In particular, the positive effects of IL-33 are related to receptor of ST2L. In turn, sST2 by binding with IL-33 sets blocking of interaction between IL-33/ST2L hence eliminating cardioprotective effects. During last years, the knowledge about the role of ST2 in pathophysiology of cardio-vascular diseases broadened and now the role of ST2 is related to myocardium dysfunction, fibrosis and remodeling. The system IL-33/ST2L, besides its myocardial role, can play an additional role in development and progressing of atherosclerosis. The system IL-33/ST2L can have a therapeutic potential in case of myocardial overload or trauma. On the contrary, sST2 acts as a false receptor of IL-33 blocking cardioprotective effects of interaction of IL-33/ST2L.
ST2是白细胞介素I（IL-I）受体家族的成员，由两种异构体组成：细胞型跨膜异构体（ST2L）和可溶性或循环型异构体（sST2）。ST2是IL-33的受体，IL-33是一种类似IL-I的细胞因子。IL-33通过与由辅助蛋白ST2L和IL-IR组成的受体复合物结合来发挥其细胞功能。IL-33/ST2系统在心肌细胞和成纤维细胞中因机械刺激或损伤而被激活。已证明IL-33与ST2L之间的相互作用具有心脏保护作用。实验模型用于证明在IL-33与ST2L相互作用时，心肌纤维化减少、心肌细胞肥大发展得到预防、细胞凋亡减少以及心肌功能能力改善。特别是，IL-33的积极作用与ST2L受体有关。反过来，sST2通过与IL-33结合阻断IL-33/ST2L之间的相互作用，从而消除心脏保护作用。在过去几年中，关于ST2在心血管疾病病理生理学中的作用的知识得到了扩展，现在ST2的作用与心肌功能障碍、纤维化和重塑有关。IL-33/ST2L系统除了在心肌方面的作用外，在动脉粥样硬化的发展和进展中可能还发挥额外作用。在心肌负荷过重或创伤的情况下，IL-33/ST2L系统可能具有治疗潜力。相反，sST2作为IL-33的假受体，阻断IL-33/ST2L相互作用的心脏保护作用。
