营养不良中的白细胞介素-1
Interleukin-1 in malnutrition.
作者信息
Bhaskaram P, Sivakumar B
出版信息
Arch Dis Child. 1986 Feb;61(2):182-5. doi: 10.1136/adc.61.2.182.
Abstract
The effect of malnutrition on the in vitro production of interleukin-1 by lipopolysaccharide stimulated circulating monocytes has been investigated in children suffering from kwashiorkor and marasmus. The interleukin-1 activity was significantly lower in children with severe malnutrition. Furthermore, macrophages from children with kwashiorkor produced factors that suppressed mouse thymocyte proliferation. These observations show a significant impairment of macrophage function and provide a mechanism for the suppression of cellular immunity in malnutrition.
摘要
在患有夸休可尔症和消瘦症的儿童中，研究了营养不良对脂多糖刺激的循环单核细胞体外产生白细胞介素-1的影响。严重营养不良儿童的白细胞介素-1活性显著降低。此外，夸休可尔症儿童的巨噬细胞产生抑制小鼠胸腺细胞增殖的因子。这些观察结果表明巨噬细胞功能存在显著损害，并为营养不良时细胞免疫抑制提供了一种机制。
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