难以捉摸的 tau 分子结构：我们能否将最近的突破转化为新的干预靶点？
The elusive tau molecular structures: can we translate the recent breakthroughs into new targets for intervention?
机构信息
Department of chemistry and biochemistry, University of California Santa Barbara, Santa Barbara, CA, 93106, USA.
Dementia Research group, School of Life Sciences, University of Sussex, Falmer, E Sussex, BN1 9QG, UK.
出版信息
Acta Neuropathol Commun. 2019 Mar 1;7(1):31. doi: 10.1186/s40478-019-0682-x.
Insights into tau molecular structures have advanced significantly in recent years. This field has been the subject of recent breakthroughs, including the first cryo-electron microscopy structures of tau filaments from Alzheimer's and Pick's disease inclusions, as well as the structure of the repeat regions of tau bound to microtubules. Tau structure covers various species as the tau protein itself takes many forms. We will here address a range of studies that help to define the many facets of tau protein structures and how they translate into pathogenic forms. New results shed light on previous data that need now to be revisited in order to up-date our knowledge of tau molecular structure. Finally, we explore how these data can contribute the important medical aspects of this research - diagnosis and therapeutics.
近年来，对 tau 分子结构的认识有了显著的进展。这一领域最近取得了一些突破，包括阿尔茨海默病和皮克病包涵体中 tau 纤维的第一张冷冻电子显微镜结构，以及与微管结合的 tau 重复区的结构。tau 结构涵盖了各种物种，因为 tau 蛋白本身有多种形式。在这里，我们将讨论一系列有助于定义 tau 蛋白结构的多个方面及其如何转化为致病形式的研究。新的结果揭示了以前的数据，现在需要重新审视这些数据，以更新我们对 tau 分子结构的认识。最后，我们探讨了这些数据如何有助于这一研究的重要医学方面——诊断和治疗。
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