Institut Européen des Membranes, UMR CNRS 5635, Université de Montpellier, Place Eugene Bataillon, 34095 Montpellier Cedex 5, France.
Institut Européen des Membranes, UMR CNRS 5635, Université de Montpellier, Place Eugene Bataillon, 34095 Montpellier Cedex 5, France.
Carbohydr Polym. 2019 May 1;211:133-140. doi: 10.1016/j.carbpol.2019.01.110. Epub 2019 Feb 1.
AB-type amphiphilic (HPMC)-PLA copolymers with various hydrophilic block lengths were synthesized using a three step procedure: ring-opening polymerization of L-lactide initiated by propynol, amination reduction of the aldehyde endgroup of HPMC, and thiol-click reaction. The resulted copolymers were characterized by NMR, DOSY-NMR, SEC and FT-IR. The cloud point (CP) was determined by UV-vis spectrometer. Data show that the HPMC block length has little effect on the Cp of the copolymers which is lower than that of HPMC. The self-assembly behavior of the copolymers was investigated from DLS, TEM, and critical micelle concentration (CMC) measurements. Spherical micelles are obtained by self-assembly of copolymers in aqueous solution. The micelle size and the CMC of copolymers increase with increasing HPMC block length. It is concluded that biobased and biodegradable (HPMC)-PLA copolymers could be promising as nano-carrier of hydrophobic drugs.
AB 型两亲性（HPMC）-PLA 共聚物具有不同的亲水性嵌段长度，采用三步法合成：丙炔醇引发的 L-丙交酯开环聚合、HPMC 醛端基的胺还原和硫醇点击反应。所得共聚物通过 NMR、DOSY-NMR、SEC 和 FT-IR 进行了表征。浊点（CP）通过紫外-可见分光光度计测定。数据表明，HPMC 嵌段长度对共聚物的 CP 影响很小，CP 低于 HPMC。通过 DLS、TEM 和临界胶束浓度（CMC）测量研究了共聚物的自组装行为。共聚物在水溶液中自组装形成球形胶束。胶束尺寸和 CMC 随 HPMC 嵌段长度的增加而增加。结论是，生物基和可生物降解的（HPMC）-PLA 共聚物有望成为疏水性药物的纳米载体。
