School of Dentistry - UniFG University Center (Faculty of Guanambi), Guanambi, Brazil.
Emeritus Professor, Department of Oral and Maxillofacial Surgery, Radboud University, Nijmegen, the Netherlands.
J Craniomaxillofac Surg. 2021 Dec;49(12):1101-1106. doi: 10.1016/j.jcms.2021.09.015. Epub 2021 Sep 28.
The odontogenic keratocyst (OKC) is a potentially aggressive odontogenic lesion and there is an ongoing debate regarding its biological behavior and classification. The present systematic review aims to assess the expression of the p53 protein in the odontogenic keratocyst in comparison to the dentigerous cyst and ameloblastoma. We searched MEDLINE, Web of Science and Scopus for immunohistochemical studies reporting OKC's, dentigerous cysts and solid/multicystic ameloblastomas. The Risk Difference between the lesions expressing the p53 was the effect measure and a P value < 0.05 was considered to provide evidence to the effect estimates. Results: The first hit retrieved 126 records. After duplicates removal, there were 84 articles, of which eighteen were assessed for eligibility. Thirteen articles were included in the meta-analysis, showing that OKC's have an estimated difference of 23% (P < 0.003) in the probability to express the p53 over dentigerous cysts, and an estimated difference of 4% (P = 0.28) in the probability to express the p53 over ameloblastomas. OKCs seem to behave more similarly to a tumor rather than an odontogenic cyst regarding its p53 expression and the classification of this lesion into Keratocystic Odontogenic Tumor should be carefully revaluated.
牙源性角化囊肿（OKC）是一种具有潜在侵袭性的牙源性病变，其生物学行为和分类仍存在争议。本系统评价旨在评估 p53 蛋白在牙源性角化囊肿中的表达，并与含牙囊肿和造釉细胞瘤进行比较。我们检索了 MEDLINE、Web of Science 和 Scopus 中报道 OKC、含牙囊肿和实性/多囊性造釉细胞瘤的免疫组织化学研究。病变表达 p53 的风险差异是效应量，p 值<0.05 被认为是对效应估计的证据。结果：首次检索到 126 条记录。去除重复项后，有 84 篇文章，其中 18 篇被评估为符合条件。13 篇文章纳入荟萃分析，结果表明 OKC 表达 p53 的概率估计比含牙囊肿高 23%（P<0.003），表达 p53 的概率比造釉细胞瘤高 4%（P=0.28）。OKC 似乎在其 p53 表达方面表现得更像肿瘤而不是牙源性囊肿，因此应仔细重新评估该病变的分类为角化囊性牙源性肿瘤。
