Carroll S B, Scott M P
Cell. 1986 Apr 11;45(1):113-26. doi: 10.1016/0092-8674(86)90543-x.
The establishment of the segmental body pattern of Drosophila requires the coordinated functions of three classes of zygotically active genes early in development. We have examined the effects of mutations in these genes on the spatial expression of the fushi tarazu (ftz) pair-rule segmentation gene. Mutations in four gap loci and in three pair-rule loci dramatically affect the initial pattern of transverse stripes of ftz-containing nuclei. Five other pair-rule genes and several other loci that affect the larval cuticular pattern do not detectably affect ftz expression. No simple regulatory relationships can be deduced. Rather, expression of the ftz gene depends upon the interactions among the different segmentation genes active at each position along the anterior-posterior axis of the early embryo.
果蝇体节模式的建立需要三类合子激活基因在发育早期发挥协同作用。我们研究了这些基因中的突变对分节基因ftz（腹节缺失）横向条纹空间表达的影响。四个缺口基因座和三个成对规则基因座中的突变显著影响含ftz细胞核横向条纹的初始模式。另外五个成对规则基因和其他几个影响幼虫表皮模式的基因座对ftz表达没有明显影响。无法推导出简单的调控关系。相反，ftz基因的表达取决于早期胚胎前后轴上每个位置活跃的不同分节基因之间的相互作用。
