Dubai Hospital, Dubai, United Arab Emirates.
Beni Suef University, Beni Suef, Egypt.
Diabetes Res Clin Pract. 2019 May;151:275-284. doi: 10.1016/j.diabres.2019.02.020. Epub 2019 Feb 27.
We aimed to describe the characteristics and care of participants with diabetes during Ramadan in the Middle East and North Africa (MENA).
In this prospective, observational study, we analysed the number of fasted days, number of participants fasting, glycemic control, rate of hypoglycemic events, and lifestyle patterns for participants with T2DM during Ramadan 2016.
The population included 1749 participants with T2DM. The mean (SD) duration of fasting was 27.7 (5.0) days, and 57.3% of participants fasted for the full duration of Ramadan. Following Ramadan, a significant improvement in HbA1c, FPG, and PPG was observed (p < 0.0001). Confirmed hypoglycemia increased significantly from before to during Ramadan (incidence: 4.9% vs. 10.4%, p < 0.001; adverse events: 0.11 vs. 0.22 events/month/participant, p < 0.001) and was dependent on the treatment regimen. Severe hypoglycemia incidence was 0.2% before versus 0.9% during Ramadan (p = 0.031), whereas adverse events remained comparable (0.01 events/month/participant; p = 0.154). Most participants (97.4%) reported lifestyle changes during Ramadan.
This prospective study is the first to describe the characteristics and care of participants with T2DM during Ramadan in MENA, and can be utilized in the development of evidence-based care to ensure the safety of participants who fast.
本研究旨在描述中东和北非（MENA）地区糖尿病患者在斋月期间的特征和护理情况。
本前瞻性观察性研究分析了 2016 年斋月期间 T2DM 患者的禁食天数、禁食人数、血糖控制情况、低血糖事件发生率和生活方式。
该人群包括 1749 例 T2DM 患者。平均（SD）禁食时间为 27.7（5.0）天，57.3%的参与者会在整个斋月期间禁食。斋月后，HbA1c、FPG 和 PPG 显著改善（p<0.0001）。与斋月前相比，确诊低血糖的发生率显著增加（发生率：4.9%比 10.4%，p<0.001；不良事件：0.11 比 0.22 事件/月/参与者，p<0.001），且与治疗方案有关。斋月前低血糖发生率为 0.2%，而斋月期间为 0.9%（p=0.031），但不良事件相似（0.01 事件/月/参与者；p=0.154）。大多数参与者（97.4%）报告在斋月期间改变了生活方式。
本前瞻性研究首次描述了 MENA 地区 T2DM 患者在斋月期间的特征和护理情况，可用于制定基于证据的护理方案，以确保参加斋戒的患者的安全。
