London School of Hygiene and Tropical Medicine, United Kingdom.
London School of Hygiene and Tropical Medicine, United Kingdom.
Int J Infect Dis. 2019 Mar;80S:S13-S16. doi: 10.1016/j.ijid.2019.02.037. Epub 2019 Feb 27.
Until the three ongoing randomised controlled trials of preventive therapy are completed, there remains a large knowledge gap about how individuals known to have been exposed to multidrug-resistant TB (MDR-TB) should be managed. The evolving paradigms and improving outcomes from treatment of active MDR-TB disease play in to discussions about the relative merits and importance of intensive surveillance and/or preventive therapy for MDR-TB contacts.
在三项正在进行的预防性治疗随机对照试验完成之前,对于已知接触过耐多药结核病(MDR-TB)的个体应如何管理,仍存在很大的知识空白。针对 MDR-TB 接触者进行强化监测和/或预防性治疗的相对优点和重要性的讨论,受到了治疗活动性 MDR-TB 疾病的不断发展的范例和改善结局的影响。