Department of Epidemiology, Lala Ram Sarup Institute of Tuberculosis and Respiratory Diseases, New Delhi, India.
Int J Tuberc Lung Dis. 2011 Oct;15(10):1326-30. doi: 10.5588/ijtld.10.0564.
Lala Ram Sarup Institute of Tuberculosis and Respiratory Diseases (LRS), a tertiary level tuberculosis (TB) institute in Delhi, India.
To study the profile of TB among household contacts of multidrug-resistant TB (MDR-TB) patients.
In a cross-sectional study, contacts of MDRTB patients were traced and clinical, radiological, bacteriological and pulmonary function tests were performed for evidence of TB infection and active disease.
Between January 2005 and December 2008, 58 of 92 index MDR-TB patients could be traced. Of 302 contacts who could be studied, 16 (5.29%) developed TB: nine had pulmonary and seven had extra- pulmonary disease; two (0.66%) had MDR-TB. Of the 302 contacts, 137 reported to the LRS Institute and were investigated. The most common symptoms observed were cough, chest pain and fever. The tuberculin skin test was positive in 109 of 135 (80.7%) contacts; among these, bacille Calmette-Guérin scar was present in 86. Pulmonary function tests revealed obstruction, restriction and mixed abnormalities.
The majority of contacts of MDR-TB patients had drug-susceptible TB and the rate of MDRTB was very low. Evaluation of contacts of MDR-TB cases may lead to early diagnosis and prevention of TB.
印度德里的拉腊·拉姆·萨鲁普结核病和呼吸系统疾病研究所（LRS）是一家三级结核病（TB）研究所。
研究耐多药结核病（MDR-TB）患者家庭接触者中结核病的发病情况。
在一项横断面研究中，对 MDRTB 患者的接触者进行了追踪，并对其进行了临床、放射学、细菌学和肺功能检查，以确定是否存在结核感染和活动性疾病。
2005 年 1 月至 2008 年 12 月，92 例索引 MDR-TB 患者中有 58 例可追踪。在可研究的 302 名接触者中，有 16 人（5.29%）发生了结核病：9 人患有肺部疾病，7 人患有肺外疾病；2 人（0.66%）患有 MDR-TB。在 302 名接触者中，有 137 人到 LRS 研究所报到并接受了调查。最常见的症状是咳嗽、胸痛和发热。135 名接触者中的 109 名（80.7%）结核菌素皮肤试验阳性；其中 86 名有卡介苗疤痕。肺功能检查显示存在阻塞、限制和混合异常。
大多数 MDR-TB 患者的接触者患有药物敏感型结核病，MDR-TB 的发病率非常低。对 MDR-TB 病例的接触者进行评估可能有助于早期诊断和预防结核病。
