Dawes P T, Smith D H, Scott D L
Clin Rheumatol. 1986 Jan;5(1):62-5. doi: 10.1007/BF02030969.
We report four cases of massive eosinophilia (greater than 1.5 X 10(9)/l) a phenomenon uncommon in rheumatoid arthritis. In two patients it preceded therapy with second line anti-rheumatic drugs. The others developed it during therapy with penicillamine and gold, though neither had an adverse reaction. It appears there are two patterns of massive eosinophilia in RA; one is related to the disease process the other to drug therapy. It does not necessarily predict adverse drug reactions nor preclude treatment with anti-rheumatic therapy.
我们报告了4例大量嗜酸性粒细胞增多（大于1.5×10⁹/L）的病例，这在类风湿关节炎中是一种不常见的现象。在2例患者中，该现象先于二线抗风湿药物治疗出现。另外2例患者在青霉胺和金制剂治疗期间出现大量嗜酸性粒细胞增多，尽管二者均未出现不良反应。类风湿关节炎中似乎存在两种大量嗜酸性粒细胞增多的模式；一种与疾病进程有关，另一种与药物治疗有关。它不一定预示药物不良反应，也不排除抗风湿治疗。
